Evidence map›Paper›PMID 36479906›Full record

ArticleGlia2023

Kir4.1 is specifically expressed and active in non-myelinating Schwann cells.

Nicole M Procacci, Robert Louis Hastings, Aamir A Aziz, Nina M Christiansen, Jie Zhao, Claire DeAngeli, Normand LeBlanc, Lucia Notterpek, Gregorio Valdez, Thomas W Gould

Open access · greenAbstract read
In one paragraph

Article in Glia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Astrocyte gap junctions and KFrontiers in cellular neuroscience · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nicole M ProcacciDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, USA.
Robert Louis HastingsDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, USA.
Aamir A AzizDepartment of Pharmacology, University of Nevada School of Medicine, Reno, Nevada, USA.
Nina M ChristiansenDepartment of Pharmacology, University of Nevada School of Medicine, Reno, Nevada, USA.
Jie ZhaoDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, USA.
Claire DeAngeliDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, USA.
Normand LeBlancDepartment of Pharmacology, University of Nevada School of Medicine, Reno, Nevada, USA.
Lucia NotterpekDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, USA.
Gregorio ValdezDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, USA.
Thomas W GouldDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, USA.ORCID 0000-0003-2154-9388
University of Nevada, Reno · USBrown University · US

Funding

Smooth Muscle Plasticity: A COBREP20GM103513 · NIGMS · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2012 to 2013
$4.1M
Predoctoral Training in the Molecular Biology of AgingT32AG041688 · NIA · BROWN UNIVERSITY · PI NICOLA NERETTI, John M Sedivy · 2012 to 2026
$3.5M
Probing the terminal / perisynaptic Schwann cell transcriptome in early stages of motor neuron disease using a RiboTag approach.R21NS107922 · NINDS · UNIVERSITY OF NEVADA RENO · PI GOULD, THOMAS · 2018 to 2019
$392k
NIA NIH HHS T32 AG041688NIGMS NIH HHS P20 GM103513NINDS NIH HHS R21 NS107922
6 · The paper itself

Abstract

Non-myelinating Schwann cells (NMSC) play important roles in peripheral nervous system formation and function. However, the molecular identity of these cells remains poorly defined. We provide evidence that Kir4.1, an inward-rectifying K+ channel encoded by the KCNJ10 gene, is specifically expressed and active in NMSC. Immunostaining revealed that Kir4.1 is present in terminal/perisynaptic SCs (TPSC), synaptic glia at neuromuscular junctions (NMJ), but not in myelinating SCs (MSC) of adult mice. To further examine the expression pattern of Kir4.1, we generated BAC transgenic Kir4.1-CreER

Indexed as

Myelin SheathSchwann CellsAnimalsMiceMice, TransgenicSciatic NerveTamoxifenTamoxifengliaKir4.1myelinationneuromuscular junctionSchwann cellssynapse

Identifiers

PMID36479906
PMCPMC9931657
OpenAlexW4310937768

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.