ReviewCurrent rheumatology reports2023
The Interplay of Biomechanical and Biological Changes Following Meniscus Injury.
Review in Current rheumatology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- Multi-Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Meniscal tissue engineering: Bridging clinical needs and experimental innovation.Journal of orthopaedic translation · 2026Review
- Spatial Characterization of the Human Meniscus: Bridging Biomechanics and Biochemistry Using Atomic Force Microscopy Micro-Indentation and Mass Spectrometry Imaging.Small methods · 2026Article
- Ten-Year Post-traumatic Osteoarthritis Incidence Is Low After Pediatric Isolated Meniscal Surgery but Lower After Meniscal Repair Than Meniscectomy.Arthroscopy, sports medicine, and rehabilitation · 2026Article
- [Advances in immunomodulatory strategies for meniscal regeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Local delivery of OSK factors enables partial cellular reprogramming to mitigate osteoarthritis and cartilage fibrosis.Experimental & molecular medicine · 2026Article
- In vivo kinematics of knee joint cartilage and meniscus contact areas under load application: a biomechanical MRI study.Archives of orthopaedic and trauma surgery · 2026Article
- Biologic Augmentation for Meniscus Repair: A Narrative Review.Bioengineering (Basel, Switzerland) · 2026Review
- Mechanical stress-induced STAT3/YAP signaling in fibroblasts programs immunosuppressive lymph node remodeling in lung squamous carcinoma.International journal of biological sciences · 2026Article
- Anisotropic wear behavior of meniscus: Influence of cross-shear and loading magnitude.Journal of the mechanical behavior of biomedical materials · 2026Article
- Inherently bioactive iron-chelating Poly (N-acryloyl 2-glycine)/chitosan hydrogel scaffolds orchestrating dual hypoxic-immune microenvironment for functional meniscus regeneration.Bioactive materials · 2025Article
- An All-Inside All-Suture Technique for Meniscal Allograft Transplantation: The Chinese Way.Arthroscopy techniques · 2025Article
- The crosstalk among macrophages, chondrocytes and mesenchymal stem cells in osteoarthritis: the role of extracellular vesicles.Stem cell research & therapy · 2025Review
- Current Rehabilitation Principles Following Meniscus Repairs.Current reviews in musculoskeletal medicine · 2025Review
- Athletic Performance at the National Football League Scouting Combine After Arthroscopic Meniscal Surgery.Orthopaedic journal of sports medicine · 2025Article
- Long-Term Results for Meniscus Repair.Current reviews in musculoskeletal medicine · 2025Review
- Meniscus Root Repairs Are Associated With High Rates of Postoperative Deep Vein Thrombosis.Orthopaedic journal of sports medicine · 2025Article
- Precision repair of zone-specific meniscal injuries using a tunable extracellular matrix-based hydrogel system.Bioactive materials · 2025Article
- The Meniscus: Basic Science and Therapeutic Approaches.Journal of clinical medicine · 2025Review
- Intra-articular Injections of CXCR4-Overexpressing Human Cartilage-Derived Progenitor Cells Improve Meniscus Healing and Protect Against Posttraumatic Osteoarthritis in Immunocompetent Rabbits.The American journal of sports medicine · 2025Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewMeniscus injury often leads to joint degeneration and post-traumatic osteoarthritis (PTOA) development. Therefore, the purpose of this review is to outline the current understanding of biomechanical and biological repercussions following meniscus injury and how these changes impact meniscus repair and PTOA development. Moreover, we identify key gaps in knowledge that must be further investigated to improve meniscus healing and prevent PTOA. RECENT
findingsFollowing meniscus injury, both biomechanical and biological alterations frequently occur in multiple tissues in the joint. Biomechanically, meniscus tears compromise the ability of the meniscus to transfer load in the joint, making the cartilage more vulnerable to increased strain. Biologically, the post-injury environment is often characterized by an increase in pro-inflammatory cytokines, catabolic enzymes, and immune cells. These multi-faceted changes have a significant interplay and result in an environment that opposes tissue repair and contributes to PTOA development. Additionally, degenerative changes associated with OA may cause a feedback cycle, negatively impacting the healing capacity of the meniscus. Strides have been made towards understanding post-injury biological and biomechanical changes in the joint, their interplay, and how they affect healing and PTOA development. However, in order to improve clinical treatments to promote meniscus healing and prevent PTOA development, there is an urgent need to understand the physiologic changes in the joint following injury. In particular, work is needed on the in vivo characterization of the temporal biomechanical and biological changes that occur in patients following meniscus injury and how these changes contribute to PTOA development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.