ArticleEMBO molecular medicine2023
Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever.
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Article in EMBO molecular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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21 citing papers in PubMed, 27 citations in OpenAlex.
- Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026Review
- The lipid A acylation pattern of Coxiella burnetii prevents detection and clearance by the non-canonical inflammasome in primary murine macrophages.PLoS pathogens · 2026Article
- The cost of persistent alarm: temporal transcriptional reprogramming of macrophages from acute activation to chronic immune suppression by day 11.Frontiers in immunology · 2026Article
- Breathing and burning: metabolic control of alveolar macrophages by intracellular bacterial pathogens.Frontiers in physiology · 2026Review
- Hyperglycemia-Suppressed Acod1 Expression Contributes to Innate Immune Deficiency in Pseudomonas aeruginosa Keratitis.Investigative ophthalmology & visual science · 2025Article
- Coxiella burnetii as a model system for understanding host immune response against obligate intracellular, vacuolar pathogens.PLoS pathogens · 2025Article
- Dissecting inflammation in the immunemetabolomic era.Cellular and molecular life sciences : CMLS · 2025Review
- Review
- Review
- Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia.PLoS pathogens · 2024Article
- IRG1/Itaconate inhibits proliferation and promotes apoptosis of CD69Apoptosis : an international journal on programmed cell death · 2024Article
- Caspase-8 activity mediates TNFα production and restrictsInfection and immunity · 2024Article
- Dual proteomics of infected macrophages reveal bacterial and host players involved in the Francisella intracellular life cycle and cell to cell dissemination by merocytophagy.Scientific reports · 2024Article
- Caspase-8 activity mediates TNFα production and restrictsbioRxiv : the preprint server for biology · 2024Article
- Control of immune cell signaling by the immuno-metabolite itaconate.Frontiers in immunology · 2024Review
- Future applications of host direct therapies for infectious disease treatment.Frontiers in immunology · 2024Review
- Divergent effects of itaconate isomers onFrontiers in immunology · 2024Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever.EMBO molecular medicine · 2023Article
- Bovine blood derived macrophages are unable to controlFrontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
31 authors at 8 institutions in 2 countries.
Lisa Kohl *Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
Md Nur A Alam Siddique *Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-9732-3986
Barbara Bodendorfer *Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
Raffaela BergerInstitute of Functional Genomics, University of Regensburg, Regensburg, Germany.
Annica PreikschatMikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-1172-6195
Christoph DanielDepartment of Nephropathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Martha ÖlkeMikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
Elisabeth Liebler-TenorioInstitute of Molecular Pathogenesis, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Jena, Germany.
Jan Schulze-LuehrmannMikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
Michael MauermeirMikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
Kai-Ting YangDepartment of Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-1854-5127
Inaya HayekMikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
Manuela SzperlinskiMikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
Jennifer AndrackInstitute of Bacterial Infections and Zoonoses, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Jena, Germany.
Ulrike SchleicherMikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
Aline BozecDepartment of Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0001-8174-2118
Gerhard KrönkeDepartment of Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Peter J MurrayMax Planck Institute for Biochemistry, Martinsried, Germany.ORCID 0000-0001-6329-9802
Stefan WirtzDeutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Masahiro YamamotoImmunology Frontier Research Center, Osaka University, Osaka, Japan.
Valentin SchatzInstitute of Clinical Microbiology, University Hospital Regensburg, Regensburg, Germany.
Jonathan JantschInstitute of Clinical Microbiology, University Hospital Regensburg, Regensburg, Germany.
Peter OefnerInstitute of Functional Genomics, University of Regensburg, Regensburg, Germany.
Daniel DegrandiInstitute of Medical Microbiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Klaus PfefferInstitute of Medical Microbiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Katja Mertens-ScholzInstitute of Bacterial Infections and Zoonoses, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Jena, Germany.
Simon RauberDepartment of Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0001-8306-9334
Christian BogdanMikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-2300-0631
Katja DettmerInstitute of Functional Genomics, University of Regensburg, Regensburg, Germany.
Anja LührmannMikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0003-1224-0880
Roland LangMikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0003-0502-3677
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversitätsklinikum Erlangen · DEFriedrich-Loeffler-Institut · DEUniversity of Regensburg · DEHeinrich Heine University Düsseldorf · DEUniversity Hospital Regensburg · DEMax Planck Institute of Biochemistry · DEUbe Frontier University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection with the intracellular bacterium Coxiella (C.) burnetii can cause chronic Q fever with severe complications and limited treatment options. Here, we identify the enzyme cis-aconitate decarboxylase 1 (ACOD1 or IRG1) and its product itaconate as protective host immune pathway in Q fever. Infection of mice with C. burnetii induced expression of several anti-microbial candidate genes, including Acod1. In macrophages, Acod1 was essential for restricting C. burnetii replication, while other antimicrobial pathways were dispensable. Intratracheal or intraperitoneal infection of Acod1
Indexed as
Coxiella burnetiiQ FeverAnimalsCarboxy-LyasesHumansHydro-LyasesMacrophagesMiceSuccinatesACOD1 protein, humanAcod1 protein, mouseCarboxy-LyasesHydro-Lyasesitaconic acidSuccinatesCis-aconitate decarboxylase 1Coxiella burnetiiImmune responsive gene 1immunometabolismitaconate
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