ArticleMolecular systems biology2022
Analysis of proteome adaptation reveals a key role of the bacterial envelope in starvation survival.
Article in Molecular systems biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- E. coli prepares for starvation by dramatically remodeling its proteome in the first hours after loss of nutrients.Molecular systems biology · 2026Article
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- Differentiation between regulated and disrupted growth arrests allows tailoring of effective treatments for antibiotic persistence.Science advances · 2026Article
- Analysis of variations in cell envelope subproteome and cell length in Acinetobacter baumannii ATCC 19606International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- The Mla pathway promotesmBio · 2025Article
- Mechanistic study of a low-power bacterial maintenance state using high-throughput electrochemistry.Cell · 2024Article
- Cyclic Isothiocyanate Goitrin ImpairsPlants (Basel, Switzerland) · 2024Article
- Evolution and stability of complex microbial communities driven by trade-offs.Molecular systems biology · 2024Review
- Survival dynamics of starving bacteria are determined by ion homeostasis that maintains plasmolysis.Nature physics · 2024Article
- Single-nucleus proteomics identifies regulators of protein transport.bioRxiv : the preprint server for biology · 2024Article
- Article
- Shaping of microbial phenotypes by trade-offs.Nature communications · 2024Review
- Energy allocation theory for bacterial growth control in and out of steady state.bioRxiv : the preprint server for biology · 2024Article
- Plasticity of growth laws tunes resource allocation strategies in bacteria.PLoS computational biology · 2024Article
- A fitness trade-off between growth and survival governed by Spo0A-mediated proteome allocation constraints inScience advances · 2023Article
- Dynamic proteome trade-offs regulate bacterial cell size and growth in fluctuating nutrient environments.Communications biology · 2023Article
- Analysis of proteome adaptation reveals a key role of the bacterial envelope in starvation survival.Molecular systems biology · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Bacteria reorganize their physiology upon entry to stationary phase. What part of this reorganization improves starvation survival is a difficult question because the change in physiology includes a global reorganization of the proteome, envelope, and metabolism of the cell. In this work, we used several trade-offs between fast growth and long survival to statistically score over 2,000 Escherichia coli proteins for their global correlation with death rate. The combined ranking allowed us to narrow down the set of proteins that positively correlate with survival and validate the causal role of a subset of proteins. Remarkably, we found that important survival genes are related to the cell envelope, i.e., periplasm and outer membrane, because the maintenance of envelope integrity of E. coli plays a crucial role during starvation. Our results uncover a new protective feature of the outer membrane that adds to the growing evidence that the outer membrane is not only a barrier that prevents abiotic substances from reaching the cytoplasm but also essential for bacterial proliferation and survival.
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