Evidence map›Paper›PMID 36479493›Full record

ReviewJournal of preventive medicine and hygiene2022

Gene variants in eating disorders. Focus on anorexia nervosa, bulimia nervosa, and binge-eating disorder.

Kevin Donato, Maria Rachele Ceccarini, Kristjana Dhuli, Gabriele Bonetti, Maria Chiara Medori, Giuseppe Marceddu, Vincenza Precone, Suela Xhufi, Marsida Bushati, Dhurata Bozo and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in Journal of preventive medicine and hygiene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Disordered eating, oral health and sports.British dental journal · 2026
    Review
  5. Neurobiology and Cognition in Girls at High-Risk of Eating Disorders: Exploring Imaging-Derived Trait Markers.European eating disorders review : the journal of the Eating Disorders Association · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Ovarian hormones and eating disorders.Frontiers in psychology · 2024
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kevin DonatoDepartment of Health Sciences, University of Milan, Milan, Italy.
Maria Rachele CeccariniDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Kristjana DhuliMAGI'S LAB, Rovereto (TN), Italy.
Gabriele BonettiMAGI'S LAB, Rovereto (TN), Italy.
Maria Chiara MedoriMAGI'S LAB, Rovereto (TN), Italy.
Giuseppe MarcedduMAGI Euregio, Bolzano, Italy.
Vincenza PreconeMAGI Euregio, Bolzano, Italy.
Suela XhufiUniversity of Sports, Tirana (AL) Albania.
Marsida BushatiUniversity of Sports, Tirana (AL) Albania.
Dhurata BozoUniversity of Sports, Tirana (AL) Albania.
Tommaso BeccariDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Matteo BertelliMAGI Euregio, Bolzano, Italy.
Consorzio Interuniversitario per le Biotecnologie · ITUniversity of Milan · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eating disorders such as anorexia nervosa, bulimia nervosa and binge-eating disorder, have a deep social impact, concluding with death in cases of severe disease. Eating disorders affect up to 5% of the population in the industrialized countries, but probably the phenomenon is under-detection and under-diagnosis. Eating disorders are multifactorial disorders, resulting from the interaction between environmental triggers, psychological factors, but there is also a strong genetic component. In fact, genetic factors predispose for approximately 33-84% to anorexia nervosa, 28-83% to bulimia nervosa, and 41-57% to binge eating disorder. Twins and family studies have provided an unassailable proof on the heritability of these disorders. Other types of genetic studies, including genome-wide association studies, whole genome sequencing and linkage analysis, allowed to identify the genes and their variants associated with eating disorders and moreover global collaborative efforts have led to delineate the etiology of these disorders. Next Generation Sequencing technologies can be considered as an ideal diagnostic approach to identify not only the common variants, such as single nucleotide polymorphism, but also rare variants. Here we summarize the present knowledge on the molecular etiology and genetic determinants of eating disorders including serotonergic genes, dopaminergic genes, opioid genes, appetite regulation genes, endocannabinoid genes and vitamin D3.

Indexed as

Anorexia NervosaBinge-Eating DisorderBulimia NervosaDeveloped CountriesGenome-Wide Association StudyHumansAnorexia nervosaBinge-eating disorderBulimia nervosaEating disordersGenetic variantsGenome-wide association studies

Identifiers

PMID36479493
PMCPMC9710388
OpenAlexW4312065199

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.