Evidence map›Paper›PMID 36479479›Full record

ReviewJournal of preventive medicine and hygiene2022

Dietary supplements in lymphedema.

Gabriele Bonetti, Kristjana Dhuli, Serena Michelini, Silvia Michelini, Sandro Michelini, Maurizio Ricci, Marina Cestari, Matteo Bertelli

Open access · greenAbstract readReview
In one paragraph

Review in Journal of preventive medicine and hygiene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Gabriele BonettiMAGI'S LAB, Rovereto (TN), Italy.
Kristjana DhuliMAGI'S LAB, Rovereto (TN), Italy.
Serena MicheliniUnit of Physical Medicine, Sapienza University of Rome, Rome, Italy.
Silvia MicheliniNeurosurgery, University of Tor Vergata, Rome, Italy.
Sandro MicheliniVascular Diagnostics and Rehabilitation Service, Marino Hospital, ASL Roma 6, Marino, Italy.
Maurizio RicciDivision of Rehabilitation Medicine, Azienda Ospedaliero-Universitaria, Ospedali Riuniti di Ancona, Italy.
Marina CestariStudy Centre Pianeta Linfedema, Terni, Italy.
Matteo BertelliMAGI'S LAB, Rovereto (TN), Italy.
Azienda Ospedaliero Universitaria Ospedali Riuniti · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphedema is a chronic inflammatory disorder resulting from ineffective fluid uptake by the lymphatic system, and the effects are principally felt in the lower limbs. The condition is said to be primary when caused by genetic mutations and secondary when caused by injuries, infections, or surgery. Lymphedema, a worldwide pathology, does not have an effective therapy so far. Leukotriene B4 has recently been identified as a key molecule in lymphedema pathogenesis. Surgical, nonsurgical, and pharmacological treatments have been proposed; however, they do not cure the disease and only ameliorate the symptoms. Nutrition and nutritional status are extremely important in lymphedema physiopathology. Obesity is a comorbidity that exacerbates the risk for secondary lymphedema and constitutes a negative prognostic factor. Indeed, anti-inflammatory foods and their effects on the inflammatory state and on oxidative stress are now being investigated for their possible therapeutic role in lymphedema. Although no special diet has so far been proven to be very effective, specific dietary tips could help in alleviating the edematous state of patients with lymphedema. A few supplements have been tested for lymphedema treatment. Among them, GARLIVE

Indexed as

Dietary SupplementsLeukotriene B4HumansLeukotriene B4Dietary supplementGARLIVE®HydroxytyrosolLymphedemaNutrition

Identifiers

PMID36479479
PMCPMC9710411
OpenAlexW4311575283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.