Evidence map›Paper›PMID 36479306›Full record

ArticleBioMed research international2022

Upregulation of Glutaminyl Cyclase Contributes to ERS-Induced Apoptosis in PC12 Cells.

Qi Shang, Xi Yu, Na Ouyang, Pan Xu, Xiaojie Chen, Yinan Wang, Chenyang Li, Xiaojuan Wang, Xifeng Lu, Chenshu Xu and 1 more

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Qi ShangSchool of Basic Medical Sciences, Health Science Center, Shenzhen University, Shenzhen, China.
Xi YuSchool of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China.
Na OuyangSchool of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China.
Pan XuSchool of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China.
Xiaojie ChenSchool of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China.
Yinan WangSchool of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China.
Chenyang LiSchool of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China.
Xiaojuan WangSchool of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China.
Xifeng LuSchool of Basic Medical Sciences, Health Science Center, Shenzhen University, Shenzhen, China.
Chenshu XuSchool of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China.ORCID https://orcid.org/0000-0002-8799-1913
Haiqiang WuSchool of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China.ORCID https://orcid.org/0000-0003-3979-7304
Shenzhen University Health Science Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glutaminyl cyclase (QC) is responsible for converting the N-terminal glutaminyl and glutamyl of the proteins into pyroglutamate (pE) through cyclization. It has been confirmed that QC catalyzes the formation of neurotoxic pE-modified A

Indexed as

AminoacyltransferasesApoptosisEndoplasmic Reticulum StressAnimalsComputational BiologyPC12 CellsRatsAminoacyltransferasesglutaminyl-peptide cyclotransferase

Identifiers

PMID36479306
PMCPMC9722295
OpenAlexW4310182856

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.