Evidence map›Paper›PMID 36479204›Full record

ArticleFrontiers in pharmacology2022

Paeoniflorin alleviates 17α-ethinylestradiol-induced cholestasis

Rulin Wang, Tengteng Yuan, Jing Sun, Menghuan Yang, Yunna Chen, Lei Wang, Yanyan Wang, Weidong Chen, Daiyin Peng

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Mitigation ofMicrobiology spectrum · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rulin WangCollege of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Tengteng YuanCollege of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Jing SunDepartment of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Menghuan YangCollege of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Yunna ChenAnhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui, China.
Lei WangCollege of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Yanyan WangCollege of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Weidong ChenCollege of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Daiyin PengCollege of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Anhui University of Traditional Chinese Medicine · CNFirst Affiliated Hospital of Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholestasis, characterized by disturbance of bile formation, is a common pathological condition that can induce several serious liver diseases. As a kind of trigger, estrogen-induced cholestasis belongs to drug-induced cholestasis. Paeoniflorin is the most abundant bioactive constituent in

Indexed as

17α-ethinylestradiolbile acidcholestasisfarnesoid X receptor (FXR)paeoniflorin (Pae)UHPLC-MS/MS

Identifiers

PMID36479204
PMCPMC9719974
OpenAlexW4309744078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.