Evidence map›Paper›PMID 36479143›Full record

ArticleJournal of multimorbidity and comorbidity

Multidimensional trajectories of multimorbidity, functional status, cognitive performance, and depressive symptoms among diverse groups of older adults.

Ana R Quiñones, Corey L Nagel, Anda Botoseneanu, Jason T Newsom, David A Dorr, Jeffrey Kaye, Stephen M Thielke, Heather G Allore

Abstract read
In one paragraph

Article in Journal of multimorbidity and comorbidity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Association of multimorbidity trajectories from early adulthood through middle age with middle-age physical function.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
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  14. Recommendations on Methods for Assessing Multimorbidity Changes Over Time: Aligning the Method to the Purpose.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ana R QuiñonesDepartment of Family Medicine, Oregon Health & Science University, Portland, OR, USA.
Corey L NagelCollege of Nursing, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Anda BotoseneanuDepartment of Health & Human Services, University of Michigan, Dearborn, MI, USA.
Jason T NewsomDepartment of Psychology, Portland State University, Portland, OR, USA.
David A DorrDepartment of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR, USA.
Jeffrey KayeDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
Stephen M ThielkeDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.
Heather G AlloreDepartment of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.

Funding

Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Denise Esserman · 2002 to 2026
$37.9M
Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2M
Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KEVIN M DUFF, Lisa C Silbert · 2020 to 2026
$28.6M
Multimorbidity Combinations and Dementia Onset Among Race/Ethnic Older AdultsRF1AG058545 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI QUINONES, ANA ROMAN · 2019 to 2019
$3.6M
Changes in Multimorbidity and Disability Among Race/Ethnic Older Adults (Administrative Supplement)R01AG055681 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI QUINONES, ANA ROMAN · 2017 to 2021
$2.8M
NIA NIH HHS P30 AG021342NIA NIH HHS P30 AG066508NIA NIH HHS P30 AG066518NIA NIH HHS R01 AG055681NIA NIH HHS RF1 AG058545
6 · The paper itself

Abstract

Background: Inter-relationships between multimorbidity and geriatric syndromes are poorly understood. This study assesses heterogeneity in joint trajectories of somatic disease, functional status, cognitive performance, and depressive symptomatology. Methods: We analyzed 16 years of longitudinal data from the Health and Retirement Study (HRS, 1998-2016) for n = 11,565 older adults (≥65 years) in the United States. Group-based mixture modeling identified latent clusters of older adults following similar joint trajectories across domains. Results: We identified four distinct multidimensional trajectory groups: (1) Conclusions: There is substantial heterogeneity in combined trajectories of interrelated health domains in late life. Membership in the two most impaired classes was more likely for minoritized older adults.

Indexed as

Cognitiondepressionjoint trajectoriesmultimorbidity

Identifiers

PMID36479143
PMCPMC9720836

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.