Evidence map›Paper›PMID 36479111›Full record

Trial reportFrontiers in immunology2022

Short-term oral pre-exposure prophylaxis against HIV-1 modulates the transcriptome of foreskin tissue in young men in Africa.

Stefan Petkov, Carolina Herrera, Laura Else, Limakatso Lebina, Daniel Opoka, Thabiso B Seiphetlo, Azure-Dee Ap Pillay, Susan Mugaba, Patricia Namubiru, Geoffrey Odoch and 9 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 4 countries.

Stefan PetkovDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Carolina HerreraDepartment of Infectious Disease, Imperial College London, London, United Kingdom.
Laura ElseDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.
Limakatso LebinaPerinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Daniel OpokaMedical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Thabiso B SeiphetloPerinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Azure-Dee Ap PillayPerinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Susan MugabaMedical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Patricia NamubiruMedical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Geoffrey OdochMedical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Andrew S SsemataMedical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Jennifer SerwangaMedical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Pontiano KaleebuMedical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Emily L WebbLondon School of Hygiene & Tropical Medicine, London, United Kingdom.
Saye KhooDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.
Neil MartinsonPerinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Clive M GrayDivision of Molecular Biology and Human Genetics, Biomedical Research Institute, Stellenbosch University, Cape Town, South Africa.
Julie FoxLife Sciences & Medicine, King's College London, London, United Kingdom.
Francesca ChiodiDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
London School of Hygiene & Tropical Medicine · GBUganda Virus Research Institute · UGPerinatal HIV Research Unit · ZAKarolinska Institutet · SEUniversity of Liverpool · GBImperial College London · GBKing's College London · GBStellenbosch University · ZAUniversity of the Witwatersrand · ZA

Funding

Medical Research Council MC_UU_00027/1Medical Research Council MR/R010161/1
6 · The paper itself

Abstract

Whilst short-term oral pre-exposure prophylaxis (PrEP) with antiretroviral drugs in men who have sex with men has shown protection against HIV-1 infection, the impact of this regimen on the

Indexed as

HIV-1Pre-Exposure ProphylaxisSexual and Gender MinoritiesDEAD-box RNA HelicasesHomosexuality, MaleHumansIon ChannelsMaleMethyltransferasesSouth AfricaCLNS1A protein, humanDDX27 protein, humanDEAD-box RNA HelicasesIon ChannelsMethyltransferasesMETTL17 protein, humanemtricitabine tenofovirforeskininflammationmitochondrial functionpre-exposure prophylaxis PrEPtranscriptomes

Identifiers

PMID36479111
PMCPMC9720390
OpenAlexW4309739997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.