ReviewFrontiers in neurology2022
The role of the piriform cortex in temporal lobe epilepsy: A current literature review.
Review in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Immature Neurons in the Postnatal Brain: Markers, Modulation, and Involvement in Normal and Aberrant Plasticity.International journal of molecular sciences · 2026Review
- Perirhinal cortex gains control of hippocampal seizures via broad downstream circuits in male mouse models.Nature communications · 2026Article
- Regional and Temporal Patterns of Long-Term Pseudorabies Virus Detection and Neuropathology in the Murine CNS.Pathogens (Basel, Switzerland) · 2026Article
- Mesial temporal lobe epilepsy with hippocampal sclerosis: Seizure, neuropsychological, and quality of life outcomes of 100 patients treated with trans-anterior T1 selective amygdalohippocampectomy.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Divergent Propagation Networks Define Two Pathophysiologically Distinct Electroclinical Phenotypes in Mesial Temporal Lobe Epilepsy.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Piriform seizures mediated by the piriform-entorhino-dentate circuit induce brain-wide functional reorganization in mice.PLoS biology · 2026Article
- The Exchange Breathing Method for Seizure Intervention: A Historical and Scientific Review of Epilepsy and Its Evolving Therapeutic Paradigms.Journal of personalized medicine · 2025Review
- The intraoperative SEEG andActa neurochirurgica · 2025Article
- Input-output organization of the mouse BLA-projecting IL neurons.Frontiers in neuroscience · 2025Article
- Human olfaction: odour coding and cross-modal concept representation in single olfactory cortex neurons.Signal transduction and targeted therapy · 2024Article
- Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application.Frontiers in neurology · 2023Review
- Minocycline prevents hypoxia-induced seizures.Frontiers in neural circuits · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temporal lobe epilepsy is the most common form of focal epilepsy and can have various detrimental consequences within many neurologic domains. Recent evidence suggests that the piriform cortex may also be implicated in seizure physiology. The piriform cortex is a primary component of the olfactory network and is located at the junction of the frontal and temporal lobes, wrapping around the entorhinal sulcus. Similar to the hippocampus, it is a tri-layered allocortical structure, with connections to many adjacent regions including the orbitofrontal cortex, amygdala, peri- and entorhinal cortices, and insula. Both animal and human studies have implicated the piriform cortex as a critical node in the temporal lobe epilepsy network. It has additionally been shown that resection of greater than half of the piriform cortex may significantly increase the odds of achieving seizure freedom. Laser interstitial thermal therapy has also been shown to be an effective treatment strategy with recent evidence hinting that ablation of the piriform cortex may be important for seizure control as well. We propose that sampling piriform cortex in intracranial stereoelectroencephalography (sEEG) procedures with the use of a temporal pole or amygdalar electrode would be beneficial for further understanding the role of the piriform cortex in temporal lobe epilepsy.
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