Evidence map›Paper›PMID 36478892›Full record

ArticleFrontiers in reproductive health2022

Pre-clinical evaluation of antiproteases as potential candidates for HIV-1 pre-exposure prophylaxis.

Carolina Herrera, Natalia Olejniczak, Laura Noël-Romas, Frank Plummer, Adam Burgener

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in reproductive health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 4 countries.

Carolina HerreraImmunology of Infection, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.
Natalia OlejniczakImmunology of Infection, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.
Laura Noël-RomasDepartment of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, United States.
Frank PlummerDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
Adam BurgenerDepartment of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, United States.
Imperial College London · GBUniversity of Manitoba · CACenter for Global Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies on highly HIV-1-exposed, yet persistently seronegative women from the Punwami Sex Worker cohort in Kenya, have shed light on putative protective mechanisms, suggesting that mucosal immunological factors, such as antiproteases, could be mediating resistance to HIV-1 transmission in the female reproductive tract. Nine protease inhibitors were selected for this study: serpin B4, serpin A1, serpin A3, serpin C1, cystatin A, cystatin B, serpin B13, serpin B1 and α-2-macroglobulin-like-protein 1. We assessed in a pilot study, the activity of these antiproteases with cellular assays and an

Indexed as

antiproteasesecto-cervixHESNHIV-1pre-exposure prophylaxistissue explants

Identifiers

PMID36478892
PMCPMC9720403
OpenAlexW4309447787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.