ArticleJCPP advances2022
Preschool development, temperament and genetic liability as early markers of childhood ADHD: A cohort study.
Article in JCPP advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Genome-wide association studies of infant and toddler temperament in European and multi-ancestry populations.Nature human behaviour · 2026Pooled it
- The reporting and handling of missing data in genetic epidemiological studies of mental health in childhood and adolescence: A systematic review.JCPP advances · 2026Article
- From ADHD Diagnosis to Meaning: Does Grief Theory Enhance Our Understanding of Narrative Reconstruction?Brain sciences · 2025Review
- Temperament Profiles at Age 18 Months as Distinctive Predictors of Elevated ASD- and ADHD-Trait Scores and Their Co-Occurrence at Age 8-9: HBC Study.Research on child and adolescent psychopathology · 2025Article
- Regulatory problems and developmental psychopathology within the first 2 years of living-a nested in cohort population-based study.Frontiers in child and adolescent psychiatry · 2024Article
- A randomized controlled trial on the digital socio-emotional competence training Zirkus Empathico for preschoolers.NPJ science of learning · 2023Article
- Delineating early developmental pathways to ADHD: Setting an international research agenda.JCPP advances · 2023Article
- Executive function profiles of preschool children with autism spectrum disorder and attention-deficit/hyperactivity disorder: A systematic review.JCPP advances · 2023Article
- Polygenic risk scores and early manifestations of attention-deficit/hyperactivity disorder.JCPP advances · 2022Article
- Challenges and opportunities for the early identification of ADHD across multiple levels of analysis - A reflection on Tobarra-Sanchez et al. (2022).JCPP advances · 2022Article
- Preschool development, temperament and genetic liability as early markers of childhood ADHD: A cohort study.JCPP advances · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Background: ADHD is associated with multiple adverse outcomes and early identification is important. The present study sets out to identify early markers and developmental characteristics during the first 30 months of life that are associated with ADHD 6 years later. Methods: 9201 participants from the prospective Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort were included. Outcome measures were parent-rated ADHD symptom scores (Strengths and Difficulties Questionnaire, SDQ) and ADHD diagnosis (Development and Wellbeing Assessment, DAWBA) at age 7. Seventeen putative markers were identified from previous literature and included: pre- and peri-natal risk factors, genetic liability (ADHD polygenic risk scores, PRS), early development, temperament scores and regulatory problems. Associations were examined using regression analysis. Results: Univariable regression analysis showed that multiple early life factors were associated with future ADHD outcomes, even after controlling for sex and socio-economic status. In a multivariable linear regression model; temperament activity scores ( Conclusion: As well as male sex and lower socio-economic status, high temperament activity levels and motor and speech delays in the first 30 months of life, are associated with childhood ADHD. Intriguingly, given that genetic risk scores are known to explain little of the variance of ADHD outcomes, we found that ADHD PRS added useful predictive information. Future research needs to test whether predictive models incorporating aspects of early development and genetic risk scores are useful for predicting ADHD in clinical practice.
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