ArticleEuropean stroke journal2022
Frequency, associated variables, and outcomes of acute myocardial injury according to the fourth Universal Definition of Myocardial Infarction in patients with acute ischemic stroke.
Article in European stroke journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 18 citations in OpenAlex.
- Acute Myocardial Injury in Spontaneous Intracerebral Hemorrhage: A Secondary Observational Analysis of the FAST Trial.Journal of the American Heart Association · 2024Trial
- Clinical Utility of Circulating Biomarkers for Diagnosis and Prognosis of Acute Stroke in the Emergency Department: A Narrative Review from Current Evidence to Clinical Implementation.Diagnostics (Basel, Switzerland) · 2026Review
- Bidirectional brain-heart interactions in health and disease.Nature reviews. Neurology · 2026Review
- Heart-brain axis pathophysiological understanding and clinical impact.Frontiers in cardiovascular medicine · 2026Review
- Myocardial injury in patients with acute ischemic stroke: Prevalence and types of triggers of myocardial demand ischemia.European stroke journal · 2026Article
- Cognitive performance in patients with ischemic stroke and additional myocardial injury - results from the multicenter prospective observational PRAISE study.Neurological research and practice · 2025Article
- Early Risk Prediction Model for Stroke-Heart Syndrome Following Endovascular Therapy.Aging and disease · 2025Article
- The spleen in ischaemic heart disease.Nature reviews. Cardiology · 2025Review
- Impact of Acute Myocardial Injury on Short- and Long-Term Outcomes in Patients With Primary Intracerebral Hemorrhage.Journal of the American Heart Association · 2025Article
- Acute Myocardial Injury in Intracerebral Hemorrhage: Smoking Gun or Innocent Bystander.Journal of the American Heart Association · 2025Article
- Mortality Risk in Patients With Cardiac Complications Following Ischemic Stroke: A Report From the Virtual International Stroke Trials Archive.Journal of the American Heart Association · 2024Article
- The Hidden Heart: Exploring Cardiac Damage Post-Stroke: A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- [Acute ischemic stroke and troponin elevation: update of the Mannheim clinical algorithm].Innere Medizin (Heidelberg, Germany) · 2024Review
- Stroke-heart syndrome: current progress and future outlook.Journal of neurology · 2024Review
- Sex Differences in Outcomes of Acute Myocardial Injury After Stroke.Journal of the American Heart Association · 2024Observational
- Heart rate turbulence in acute ischemic stroke.European stroke journal · 2024Observational
- Rising Cardiac Troponin: A Prognostic Biomarker for Mortality After Acute Ischemic Stroke.Journal of the American Heart Association · 2024Article
- Stroke-Heart Syndrome: Does Sex Matter?Journal of the American Heart Association · 2023Article
- Neuroimaging of acute myocardial injury in stroke: insights into brain lesion locations and network disconnections.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Myocardial injury as indicated by elevation of cardiac troponin levels is common after acute ischemic stroke (AIS) and linked to poor outcomes. Previous studies rarely reported on serial hs-cTn measurements to distinguish whether myocardial injury is acute or chronic. Thus, little is known about frequency, associated variables, and outcome of acute myocardial injury in AIS. Methods and patients: In this single-centered observational cohort study, from 01/2019 to 12/2020, consecutive patients with neuroimaging-confirmed AIS <48 h after symptom onset, and serial troponin measurements within the first 2 days after admission (Roche Elecsys Results: Out of 1067 analyzed patients, 25.3% had acute myocardial injury, 40.4% had chronic myocardial injury and 34.3% had no myocardial injury. Older age, higher stroke severity, thrombolytic treatment, and impaired kidney function were independently associated with acute myocardial injury. In-hospital mortality was higher in patients with acute myocardial injury than in those without (13% vs 3%, adjusted OR, 2.9% [95% CI, 1.6-5.5]). Compared with no myocardial injury, both acute and chronic myocardial injury were associated with unfavorable functional status at discharge (adjusted OR, 1.6 [95% CI, 1.1-2.5] and OR, 1.7 [95% CI, 1.2-2.4], respectively). Conclusions: A quarter of patients with AIS have evidence of acute myocardial injury according to the fourth Universal Definition of Myocardial Infarction. The strong association with in-hospital mortality highlights the need for clinical awareness and future studies on underlying mechanisms.
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