Evidence map›Paper›PMID 36478748›Full record

ArticleJournal of oncology2022

Gerardo I Magallanes-Garza, Sandra K Santuario-Facio, Saúl Lira-Albarrán, Arlina F Varela-Varela, Servando Cardona-Huerta, Pablo Ruiz-Flores, Jorge Haro-Santa-Cruz, Yadira X Perez-Paramo, Gabriela Sofia Gomez-Macias, Daniel Davila-Gonzalez and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. The role and therapeutic value of NUSAP1 in human cancers.Journal of translational medicine · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Gerardo I Magallanes-GarzaTecnologico de Monterrey, Escuela de Medicina y Ciencias de La Salud, Monterrey, Mexico.
Sandra K Santuario-FacioTecnologico de Monterrey, Escuela de Medicina y Ciencias de La Salud, Monterrey, Mexico.
Saúl Lira-AlbarránTecnologico de Monterrey, The Institute for Obesity Research, Monterrey, Mexico.
Arlina F Varela-VarelaUniversidad Autonoma de Coahuila, Centro de Investigacion Biomedica, Facultad de Medicina, Unidad Torreon, Torreon, Mexico.
Servando Cardona-HuertaTecnologico de Monterrey, Direccion Nacional de Investigacion Clinica TecSalud, Monterrey, Mexico.
Pablo Ruiz-FloresUniversidad Autonoma de Coahuila, Centro de Investigacion Biomedica, Facultad de Medicina, Unidad Torreon, Torreon, Mexico.
Jorge Haro-Santa-CruzUniversidad Autonoma de Coahuila, Centro de Investigacion Biomedica, Facultad de Medicina, Unidad Torreon, Torreon, Mexico.
Yadira X Perez-ParamoWashington State University, Pharmaceutical Sciences Department, College of Pharmacy Spokane, WA, USA.
Gabriela Sofia Gomez-MaciasTecnologico de Monterrey, Centro de Cancer de Mama, Hospital Zambrano Hellion, San Pedro Garza Garcia, Mexico.
Daniel Davila-GonzalezTecnologico de Monterrey, Escuela de Medicina y Ciencias de La Salud, Monterrey, Mexico.
Javier Valero-GomezTecnologico de Monterrey, Escuela de Medicina y Ciencias de La Salud, Monterrey, Mexico.
Gissela Borrego-SotoUniversity of Texas at Austin, Department of Molecular Biosciences, Austin, TX, USA.
Augusto Rojas-MartinezTecnologico de Monterrey, Escuela de Medicina y Ciencias de La Salud, Monterrey, Mexico.ORCID https://orcid.org/0000-0003-3765-6778
Rocio Ortiz-LopezTecnologico de Monterrey, Escuela de Medicina y Ciencias de La Salud, Monterrey, Mexico.ORCID https://orcid.org/0000-0002-7783-026X
Tecnológico de Monterrey · MXUniversidad Autónoma de Coahuila · MXUniversidad Autónoma de Nuevo León · MXHospital Zambrano Hellion · MXMexican Social Security Institute · MXThe University of Texas at Austin · USWashington State University Spokane · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To evaluate whether changes in genomic expression that occur beginning with breast cancer (BC) diagnosis and through to tumor resection after neoadjuvant chemotherapy (NCT) reveal biomarkers that can help predict therapeutic response and survival. Materials and Methods: We determined gene expression profiles based on microarrays in tumor samples from 39 BC patients who showed pathologic complete response (pCR) or therapeutic failure (non-pCR) after NCT (cyclophosphamide-doxorubicin/epirubicin). Based on unsupervised clustering of gene expression, together with functional enrichment analyses of differentially expressed genes, we selected Results: A signature of 43 differentially expressed genes discriminated pCR from non-pCR patients (|fold change >2|, false discovery rate <0.05) only in biopsies taken after surgery. Patients achieving pCR showed downregulation of Conclusions: The downregulation of

Identifiers

PMID36478748
PMCPMC9722309
OpenAlexW4310146363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.