ArticleFrontiers in cellular and infection microbiology2022
Alterations of the gut microbiota and short chain fatty acids in necrotizing enterocolitis and food protein-induced allergic protocolitis infants: A prospective cohort study.
Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 21 citations in OpenAlex.
- NEC-Associated Bronchopulmonary Dysplasia and the Gut-Lung Axis in Preterm Infants.American journal of perinatology · 2026Review
- Short-Chain Fatty Acid Supplementation After Traumatic Brain Injury Attenuates Neurologic Injury Via the Gut-Brain-Microglia Axis.Shock (Augusta, Ga.) · 2026Article
- A digestive cartridge reduces intestinal injury in a murine model of necrotizing enterocolitis.PloS one · 2026Article
- Gut microbiota alters the Th1/Th2 balance and aggravates food-allergic enteropathy in a mouse model.Bioscience of microbiota, food and health · 2026Article
- Allergic proctocolitis: Evaluation and management.Journal of food allergy · 2025Review
- The role of fecal short-chain fatty acids in neonatal necrotizing enterocolitis.Translational pediatrics · 2025Article
- Impact of oral immunotherapy on diversity of gut microbiota in food-allergic children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Rare and Intermediate Taxa Shape the Gut Bacterial Structure in Neonates and Preterm Infants with Necrotizing Enterocolitis.Journal of microbiology and biotechnology · 2025Article
- Longitudinal fecal microbiota and volatile metabolomics preceding necrotizing enterocolitis in preterm infants: a case-control study.Scientific reports · 2025Article
- Gut microbiota in infants with food protein enterocolitis.Pediatric research · 2025Article
- Differences in Gut Microbiota Composition Depending on the Site of Pain in Patients with Chronic Pain.Journal of pain research · 2025Article
- Guardian of the gut: butyrate-regulated FUT2 protects against experimental NEC.Pediatric research · 2025Article
- Clinical prediction model by machine learning to determine the results of maternal dietary avoidance in food protein-induced allergic proctocolitis infants.Frontiers in pediatrics · 2025Article
- The Role of Butyric Acid and Microorganisms in Chronic Inflammatory Diseases and Microbiome-Based Therapeutics.Journal of inflammation research · 2025Review
- Gut Microbiota-Derived Metabolites and Their Role in the Pathogenesis of Necrotizing Enterocolitis in Preterm Infants: A Narrative Review.Metabolites · 2024Review
- Struggling to Understand the NEC Spectrum-Could the Integration of Metabolomics, Clinical-Laboratory Data, and Other Emerging Technologies Help Diagnosis?Metabolites · 2024Review
- Reduced Gut Bacterial Diversity in Early Life Predicts Feeding Intolerance in Preterm Neonates.Tropical medicine and infectious disease · 2024Article
- Expression and clinical significance of short-chain fatty acids in patients with intrahepatic cholestasis of pregnancy.World journal of hepatology · 2024Article
- Microbiota-derived short chain fatty acids in pediatric health and diseases: from gut development to neuroprotection.Frontiers in microbiology · 2024Review
- Gut microbiome derived short chain fatty acids: Promising strategies in necrotising enterocolitis.Current research in microbial sciences · 2024Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Even though presenting with similar clinical manifestations, necrotizing enterocolitis (NEC) and food protein-induced allergic protocolitis (FPIAP) have completely different treatments and prognosis. Our study aimed to quantify and evaluate differences in gut microbiota and short chain fatty acids (SCFAs) between infants with NEC and FPIAP to better identify these two diseases in clinical settings. Methods: A total of 43 infants with NEC or FPIAP in Children's Hospital of Chongqing Medical University, China between December 2020 and December 2021 were enrolled. Stool samples were prospectively collected and froze. Infants defined as NEC were those who presented with clinical courses consistent with NEC and whose radiographs fulfilled criteria for Bell's stage 2 or 3 NEC, while those who were healthy in appearance and had blood in the stool (visible or may be microscopic), had normal bowel sounds in physical examination, were resolved after eliminating the causative food, and/or had recurrence of symptoms after oral food challenge (OFC) were defined as FPIAP. Primers specific for bacterial 16S rRNA genes were used to amplify and pyrosequence fecal DNA from stool samples. Gas chromatography-mass spectrometry (GC-MS) technology was used to determine the concentrations of SCFAs. Results: Among the 43 infants, 22 were diagnosed with NEC and 21 were diagnosed with FPIAP. The microbial community structure in NEC infant stools differed significantly from those in FPIAP infant stools. NEC infants had significantly higher proportion of Actinobacteria and reduced proportion of Bacteroidetes compared with FPIAP infants, and the proportions of Conclusions: The differences of gut microbiota composition and concentrations of SCFAs might represent suitable biomarker targets for early identification of NEC and FPIAP.
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