Evidence map›Paper›PMID 36478283›Full record

ArticleEuropean journal of clinical pharmacology2023

Duplicate prescriptions in the emergency department: a retrospective cohort study.

Johannes Heck, Benjamin Krichevsky, Adrian Groh, Martin Schulze Westhoff, Hans Laser, Swetlana Gerbel, Patrick-Pascal Strunz, Carsten Schumacher, Martin Klietz, Dirk O Stichtenoth and 2 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of clinical pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Johannes Heck *Institute for Clinical Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. heck.johannes@mh-hannover.de.ORCID http://orcid.org/0000-0002-5382-3014
Benjamin Krichevsky *Institute for General Practice and Palliative Care, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0001-5899-0113
Adrian GrohDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-4407-3557
Martin Schulze WesthoffDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0003-3262-8137
Hans LaserCenter for Information Management, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-0958-8600
Swetlana GerbelCenter for Information Management, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0003-3430-5294
Patrick-Pascal StrunzDepartment of Internal Medicine II, Rheumatology and Clinical Immunology, University Hospital Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-3168-7074
Carsten SchumacherCenter for Clinical Trials, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-3012-4245
Martin KlietzDepartment of Neurology, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-3054-9905
Dirk O StichtenothInstitute for Clinical Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0000-0002-6526-0917
Christoph Höner Zu Siederdissen *Emergency Department, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-8268-2345
Olaf Krause *Institute for General Practice and Palliative Care, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-9932-1116
Medizinische Hochschule Hannover · DEUniversitätsklinikum Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the nature and frequency of duplicate prescriptions (DPs) in the emergency department (ED) by utilization of a novel categorization of DPs which differentiates between appropriate DPs (ADPs) and potentially inappropriate DPs (PIDPs).

methodsIn this retrospective cohort study, adult patients who presented to the ED for internal medicine of a large university hospital in northern Germany in 2018 and 2019 were screened for the presence of DPs. Descriptive statistical methods were used to characterize the nature and frequency of PIDPs compared to the frequency of ADPs.

resultsA total of 4208 patients were enrolled into the study. The median age of the study population was 63 years (interquartile range (IQR) 48-77), 53.9% were female. The patients took a median of 5 drugs (IQR 3-9). 10.9% of the study population were affected by at least one PIDP (at least one grade-1 PIDP: 6.1%; at least one grade-2 PIDP: 4.5%; at least one grade-3 PIDP: 1.1%). Non-opioid analgesics accounted for the majority of grade-1 PIDPs, while inhalatives were most frequently responsible for grade-2 and grade-3 PIDPs. Nearly half of the study population (48.6%) displayed at least one ADP.

conclusionPIDPs pose a frequent pharmacological challenge in the ED. The medication review should comprise a systematic screening for PIDPs with a particular focus on non-opioid analgesics and inhalatives. ADPs were detected more frequently than PIDPs, questioning the predominant notion in the medical literature that DPs are exclusively deleterious.

Indexed as

Analgesics, Non-NarcoticAdultAnalgesics, OpioidDrug PrescriptionsEmergency Service, HospitalFemaleHumansInappropriate PrescribingMaleMiddle AgedPractice Patterns, Physicians'Retrospective StudiesAnalgesics, Non-NarcoticAnalgesics, OpioidDuplicate prescriptionsEmergency departmentInternal medicineMedication reviewPharmacotherapy safety

Identifiers

PMID36478283
PMCPMC9734425
OpenAlexW4311290944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.