ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2023
Descending necrotizing mediastinitis: etiopathogenesis, diagnosis, treatment and long-term consequences-a retrospective follow-up study.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- Descending necrotizing mediastinitis after pharyngeal fish bone impaction: a case report.Oxford medical case reports · 2026Article
- Endoscopic transcervical mediastinal drainage for treating descending necrotizing mediastinitis.BMC surgery · 2026Observational
- Metagenomic next-generation sequencing-guided management of descending mediastinitis and empyema caused by Segatella baroniae: a case report.BMC pulmonary medicine · 2026Article
- Recognizing Descending Necrotizing Mediastinitis in Adults: A Narrative Review of Diagnostic Dilemmas and Barriers.Cureus · 2026Review
- Prognostic drivers beyond anatomy: towards tailored surgical management in descending necrotizing mediastinitis.Updates in surgery · 2026Article
- Successful Nonsurgical Resolution of Descending Necrotizing Mediastinitis: A Case-Based Illustration of Clinical Management.Case reports in infectious diseases · 2026Article
- Acute mediastinitis, mediastinal granuloma, and fibrosing mediastinitis: a narrative review.Mediastinum (Hong Kong, China) · 2026Review
- Narrative review of descending necrotizing mediastinitis, focusing on the etiology, classification-guided surgical management, treatments, and prognosis.Mediastinum (Hong Kong, China) · 2026Review
- Descending Necrotizing Mediastinitis, When Mediastinal Drainage By Thoracoscopy Is Not Sufficient: Case Report and Review of the Literature.Clinical medicine insights. Case reports · 2026Article
- Descending necrotizing mediastinitis complicating deep neck abscesses: clinical features and prognostic assessment in 45 ICU patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Observational
- Management and Outcomes of Descending Necrotizing Mediastinitis: A 15-Year Experience.Journal of clinical medicine · 2025Article
- Risk factors and preventive measures for severe orofacial and neck infections: a three-year observational study.BMC oral health · 2025Observational
- Etiology, diagnosis, and management of descending necrotizing mediastinitis: a narrative review.Mediastinum (Hong Kong, China) · 2025Review
- Descending Necrotizing Mediastinitis: A Rare Yet Lethal Complication Demanding Timely Intervention.Cureus · 2024Article
- Multidisciplinary Management of Descending Necrotizing Mediastinitis: Is Thoracoscopic Treatment Feasible?Journal of clinical medicine · 2024Article
- Video-assisted thoracic surgery drainage is feasible and safe for acute necrotizing mediastinitis: a retrospective cohort study.Journal of thoracic disease · 2023Article
- A Machine Learning Approach to Assess Patients with Deep Neck Infection Progression to Descending Mediastinitis: Preliminary Results.Diagnostics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe primary aim of this retrospective study was to analyze the progression of descending necrotizing mediastinitis (DNM), evaluate the impact of comorbidities on complications and mortality and to observe long-term consequences of DNM on dysphagia and measurements quality of life. DNM is a serious infectious disease that requires multimodal treatment. Current literature varies in conclusions of risk factors, management and outcome of DNM. In addition, little is known about persisting effects on quality of life.
methodsRetrospective data analysis of 88 patients with DNM representing the largest single-center study. Recording data of patients and diseases as well as clinical progression from 1997 to 2018. Two questionnaires were sent to the participants to measure quality of life and to detect dysphagia.
results88 patients were included. The most frequently found pathogen were Streptococcus spp. (52%). 75% of the patients underwent multiple surgeries, mean count of surgical procedures was 4.3 times. 84% received intensive care treatment. Median length of stay on the intensive care unit was 7 days. 51% had pre-existing comorbidities associated with reduced tissue oxygenation (e.g., diabetes). The most common complication was pleural effusion (45%). During the observation period, the mortality rate was 9%. 12 questionnaires could be evaluated. 67% of the participants were affected by dysphagia at the time of the survey.
conclusionsDescending necrotizing mediastinitis (DNM) is a severe disease requiring an immediate initiation of multimodal treatment. Although quality of life usually isn´t impaired permanently, dysphagia may often persist in patients after DNM.
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