Evidence map›Paper›PMID 36478076›Full record

ArticleThe Journal of infectious diseases2023

A Growing Number of Men Who Have Sex With Men Aging With HIV (20212031): A Comparison of Two Microsimulation Models.

Emily P Hyle, Parastu Kasaie, Eli Schwamm, Cameron Stewart, Elizabeth Humes, Krishna P Reddy, Peter F Rebeiro, Tijana Stanic, Pamela P Pei, Lucas Gerace and 6 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Emily P HyleMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Parastu KasaieDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Eli SchwammMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Cameron StewartDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Elizabeth HumesDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Krishna P ReddyMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Peter F RebeiroDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Tijana StanicMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Pamela P PeiMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Lucas GeraceDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Luke AngMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-8771-7327
Kelly A GeboDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Liyang YuMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Fatma M SheblMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Kenneth A FreedbergMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Keri N AlthoffDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0002-5068-6595

Funding

North American AIDS Cohorts on Collaboration and Design (NAACCORD)U01AI069918 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Keri Nicole Althoff, RICHARD Douglas MOORE · 2006 to 2026
$65.2M
Development and application of a new simulation model for COVID-19R01AI042006 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Kenneth Alan Freedberg, Anne Neilan · 1998 to 2026
$12.9M
Novel Methods to Inform HIV/TB Clinical Trial DevelopmentR01AI093269 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI REDDY, KRISHNA P · 2011 to 2024
$6.8M
The Impact of Hearing Loss Treatment Scale-Up in Persons Aging with HIV on Dementia Risk, Quality of Life, and Healthcare CostsR01AG069575 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYLE, EMILY PARKER · 2021 to 2025
$4.6M
The Silver Tsunami: Projecting multimorbidity, polypharmacy,and healthcare costs for those aging with HIV in the USR01AG053100 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALTHOFF, KERI NICOLE · 2016 to 2020
$2.7M
Clinical and Economic Outcomes of HIV, Cigarette Smoking, and Smoking Cessation InterventionsK01DA042687 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI REDDY, KRISHNA P · 2016 to 2020
$929k
Cardiovascular Disease in South African HIV Patients: Value of PreventionK01HL123349 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HYLE, EMILY PARKER · 2016 to 2020
$896k
The HIV Care Continuum and Health Policy: Changes through Context and GeographyK01AI131895 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI REBEIRO, PETER F · 2017 to 2021
$623k
Projecting the Epidemiologic and Economic Impact of HIV Prevention Efforts in the Context of Other Sexually Transmitted InfectionsK01AI138853 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KASAIE, PARASTU · 2019 to 2023
$591k
NHLBI NIH HHS K01 HL123349NIAID NIH HHS K01 AI131895NIAID NIH HHS K01 AI138853NIAID NIH HHS R01 AI042006NIAID NIH HHS R01 AI093269NIAID NIH HHS U01 AI069918NIA NIH HHS R01 AG053100NIA NIH HHS R01 AG069575NIDA NIH HHS K01 DA042687NIH HHS R01 AI042006
6 · The paper itself

Abstract

backgroundMen who have sex with men (MSM) on antiretroviral therapy (ART) are at risk for multimorbidity as life expectancy increases. Simulation models can project population sizes and age distributions to assist with health policy planning.

methodsWe populated the CEPAC-US model with CDC data to project the HIV epidemic among MSM in the United States. The PEARL model was predominantly informed by NA-ACCORD data (20092017). We compared projected population sizes and age distributions of MSM receiving ART (20212031) and investigated how parameters and assumptions affected results.

resultsWe projected an aging and increasing population of MSM on ART: CEPAC-US, mean age 48.6 (SD 13.7) years in 2021 versus 53.9 (SD 15.0) years in 2031; PEARL, 46.7 (SD 13.2) years versus 49.2 (SD 14.6) years. We projected 548 800 MSM on ART (147 020 65 years) in 2031 (CEPAC-US) and 599 410 (113 400 65 years) (PEARL). Compared with PEARL, CEPAC-US projected a smaller population of MSM on ART by 2031 and a slower increase in population size, driven by higher estimates of disengagement in care and mortality.

conclusionsFindings from two structurally distinct microsimulation models suggest that the MSM population receiving ART in the United States will increase and age over the next decade. Subgroup-specific data regarding engagement in care and mortality can improve projections and inform health care policy planning.

Indexed as

HIV InfectionsSexual and Gender MinoritiesAge DistributionAgingHomosexuality, MaleHumansMaleMiddle AgedUnited Statesage distributionagingARTHIVmicrosimulation modelMSMUnited States

Identifiers

PMID36478076
PMCPMC10169437

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.