The non-linear associations of serum follicle-stimulating hormone levels with bone mineral density and the risk of osteoporosis during menopausal transition: an analysis of National Health and Nutrition Examination Survey data.

Zhize Liu, Huixin Tong, Bo Su, Meixue Yu, Yongjie Chen

Abstract read

In one paragraph

Article in Endocrine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors at 4 institutions in 1 country.

Zhize Liu *Department of Orthopaedics, Affiliated Dalian Municipal Central Hospital of Dalian Medical University, Dalian, 116021, China.

Huixin Tong *Department of Endocrinology, General Hospital of Northern Theater Command, Shenyang, 110016, China.

Bo SuDepartment of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.

Meixue YuHealth Management Center, Affiliated Dalian Municipal Central Hospital of Dalian Medical University, Dalian, 116021, China.

Yongjie ChenDepartment of Epidemiology and Statistics, School of Public Health, Tianjin Medical University, Tianjin, 300070, China. chenyongjie@tmu.edu.cn.ORCID 0000-0002-2559-498X

Dalian Medical University · CNGeneral Hospital of Shenyang Military Region · CNHarbin Medical University · CNTianjin Medical University · CN

Funding

National Natural Science Foundation of China 81903416

6 · The paper itself

Abstract

purposeTo explore the non-linear associations of serum FSH levels with BMD and the risk of osteoporosis in pre- and postmenopausal women.

methodsData analyzed in this study were derived from the National Health and Nutrition Examination Survey (NHANES) III and the NHANES from 1999 to 2002. Women aged from 35 to 60 years with complete data of serum FSH levels and BMD were eligible. Serum FSH levels were assayed using the Microparticle Enzyme Immunoassay technology. Lumbar spine and femur neck BMD were measured using a dual energy X-ray absorptiometry. Osteoporosis was assessed according to BMD of lumbar spine, total femur, and femur neck.

resultsThis study included 3743 women. A significant non-linear association of serum FSH levels with lumbar spine BMD was observed only in postmenopausal women (P for non-linear association = 0.013) but not in premenopausal women (P for non-linear association = 0.092). The results of femur neck BMD were comparable with those of lumbar spine BMD. Meanwhile, there was significant non-linear association of serum FSH levels with the risk of osteoporosis only in postmenopausal women (P for non-linear association = 0.050).

conclusionNon-linear associations of serum FSH levels with BMD at lumbar spine and femur neck were observed only in postmenopausal women. Meanwhile, serum FSH levels were non-linearly associated with the risk of osteoporosis in postmenopausal women.

Indexed as

Bone DensityOsteoporosisAbsorptiometry, PhotonAdultFemaleFemur NeckFollicle Stimulating HormoneHumansLumbar VertebraeMenopauseMiddle AgedNutrition SurveysFollicle Stimulating HormoneBone mineral densityFollicle-stimulating hormoneNon-linear associationOsteoporosis

Identifiers

PMID36477941

DOI10.1007/s12020-022-03278-3

OpenAlexW4310940009

What OpenQuestion holds

Textmetadata

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None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.