ArticleDiabetes care2023
Roux-en-Y Gastric Bypass Increases Glycemic Excursions During Pregnancy and Postpartum: A Prospective Cohort Study.
Article in Diabetes care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Altered postprandial glucose metabolism and enteropancreatic hormone responses during pregnancy following Roux-en-Y gastric bypass: a prospective cohort study.BMJ open diabetes research & care · 2025Trial
- Maternal Hypoglycemia and Reduced Foetal Growth in Pregnancies Following Roux-en-Y Gastric Bypass: A Prospective Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Pregnancy after bariatric surgery: a point of view on unresolved questions.Journal of endocrinological investigation · 2026Article
- Managing Gestational Diabetes Complexity with Continuous Glucose Monitoring: A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Post-bariatric Hypoglycemia Management: A Gulf Cooperation Council Consensus Statement.Journal of the Endocrine Society · 2026Article
- The outcomes of pregnancy after metabolic and bariatric surgery: a literature review.Archives of gynecology and obstetrics · 2025Review
- Prognostic significance of postoperative glycemic variability after gastric surgery: a retrospective cohort study and development of a mortality prediction model.European journal of medical research · 2025Article
- CGM profiling in Roux-en-Y gastric bypass, type 1 diabetes and healthy adults: Unmasking deviations from normoglycaemia.Diabetes, obesity & metabolism · 2025Article
- Glucose Homeostasis, Metabolomics, and Pregnancy Outcomes After Bariatric Surgery (GLORIA): Protocol for a Multicentre Prospective Cohort Study.Journal of clinical medicine · 2025Article
- Incidence of gestational diabetes in pregnant women with a history of bariatric surgery using a service evaluation.Clinical medicine (London, England) · 2025Article
- Maternal and neonatal outcomes of pregnancies after metabolic bariatric surgery: a retrospective population-based study.The Lancet regional health. Europe · 2025Article
- The association of higher offspring early-childhood weight gain with prepregnancy metabolic and bariatric surgery.Obesity (Silver Spring, Md.) · 2024Article
- Article
- Gestational Diabetes Risk and Low Birth Weight After Metabolic Bariatric Surgery: a Complex Interplay to be Balanced.Obesity surgery · 2024Article
- Pregnancy Outcomes After Bariatric Surgery: Importance of Maternal Ferritin on Birth Weight.Obesity surgery · 2024Observational
- Glucose levels measured with continuous glucose monitoring in uncomplicated pregnancies.BMJ open diabetes research & care · 2024Article
- Beyond Weight Loss: A Comprehensive Review of Pregnancy Management following Bariatric Procedures.Medicina (Kaunas, Lithuania) · 2024Review
- Increased glycemic variability in pregnant women with Roux-en-Y gastric bypass compared with sleeve gastrectomy.BMJ open diabetes research & care · 2024Observational
- Medical and Psychological Aspects of Pregnancy in Women with Obesity and after Bariatric Surgery.Nutrients · 2023Review
- Post-bariatric hypoglycaemia diagnosed during pregnancy.Endocrinology, diabetes & metabolism case reports · 2023Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRoux-en-Y gastric bypass (RYGB) and pregnancy markedly alter glucose metabolism, but evidence on glucose metabolism in pregnancy after RYGB is limited. Thus, the aims of the Bariatric Surgery and Consequences for Mother and Baby in Pregnancy study were to investigate interstitial glucose (IG) profiles during pregnancy, risk factors associated with hypoglycemia, and the association between fetal growth and hypoglycemia in pregnant women previously treated with RYGB, compared with control participants. RESEARCH DESIGN AND
methodsTwenty-three pregnant women with RYGB and 23 BMI- and parity-matched pregnant women (control group) were prospectively studied with continuous glucose monitoring in their first, second, and third trimesters, and 4 weeks postpartum. Time in range (TIR) was defined as time with an IG level of 3.5-7.8 mmol/L.
resultsWomen with RYGB were 4 years (interquartile range [IQR] 0-7) older than control participants. Pregnancies occurred 30 months (IQR 15-98) after RYGB, which induced a reduction in BMI from 45 kg/m2 (IQR 42-54) presurgery to 32 kg/m2 (IQR 27-39) prepregnancy. Women with RYGB spent decreased TIR (87.3-89.5% vs. 93.3-96.1%; P < 0.01) owing to an approximately twofold increased time above range and increased time below range (TBR) throughout pregnancy and postpartum compared with control participants. Women with increased TBR had a longer surgery-to-conception interval, lower nadir weight, and greater weight loss after RYGB. Finally, women giving birth to small-for-gestational age neonates experienced slightly increased TBR.
conclusionsWomen with RYGB were more exposed to hypoglycemia and hyperglycemia during pregnancy compared with control participants. Further research should investigate whether hypoglycemia during pregnancy in women with RYGB is associated with decreased fetal growth.
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