Evidence map›Paper›PMID 36477643›Full record

Trial reportSurgical endoscopy2023

Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a prospective clinical trial and comparative analysis.

Chae Yun Cho, Jula Veerapong, Joel M Baumgartner, James D Murphy, Andrew M Lowy, Kaitlyn J Kelly

Registry-linked trialOpen access · hybridAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Surgical endoscopy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02463877 (A Minimally-invasive Approach to Cytoreduction and HIPEC for Peritoneal Surface Malignancy), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02463877 phase2completednot on this map

A Minimally-invasive Approach to Cytoreduction and HIPEC for Peritoneal Surface Malignancy

TypeinterventionalSponsorUniversity of California, San DiegoRan2014 to 2022Enrolled18ConditionsCancerArmsMinimally-Invasive Procedure
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chae Yun ChoDepartment of Surgery, University of California, San Diego, 3855 Health Sciences Drive, Mail Code 0987, San Diego, La Jolla, CA, 92093, USA.
Jula VeerapongDepartment of Surgery, University of California, San Diego, 3855 Health Sciences Drive, Mail Code 0987, San Diego, La Jolla, CA, 92093, USA.
Joel M BaumgartnerDepartment of Surgery, University of California, San Diego, 3855 Health Sciences Drive, Mail Code 0987, San Diego, La Jolla, CA, 92093, USA.
James D MurphyDepartment of Radiation Medicine, University of California, San Diego, La Jolla, USA.
Andrew M LowyDepartment of Surgery, University of California, San Diego, 3855 Health Sciences Drive, Mail Code 0987, San Diego, La Jolla, CA, 92093, USA.
Kaitlyn J KellyDepartment of Surgery, University of California, San Diego, 3855 Health Sciences Drive, Mail Code 0987, San Diego, La Jolla, CA, 92093, USA. kjkelly3@wisc.edu.ORCID 0000-0001-9999-038X
University of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOpen cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with high morbidity, which limits the degree to which patients may benefit from this therapy. This study aimed to determine the feasibility of laparoscopic CRS/HIPEC.

methodsThis was a single institution prospective clinical trial and comparative study using historical controls. Patients with histologically confirmed peritoneal surface malignancy (PSM) of appendiceal, colorectal, ovarian, or primary peritoneal origin, peritoneal carcinomatosis index (PCI) [Formula: see text] 10 were eligible.

resultsClinical trial: 18 patients (median age 57 years, 39% female) with appendiceal (15) or colorectal (3) primary PSM underwent laparoscopic CRS/HIPEC. Median and range outcomes were: operative time 219 min (134-378), EBL 10 mL (0-100), time to return to bowel function 3 days (1-7), duration IV narcotic use 3 days (1-8), length of stay 6 days (3-11). All patients had a complete cytoreduction (CC-score 0). Three (17%) experienced minor morbidity, with no major morbidity or mortality. Median DFS and OS were not reached with median follow-up of 48 months. Comparative analysis: Laparoscopic approach associated with reduced time to return of bowel function (3 versus 4 days, p = 0.001), length of stay (8 versus 5 days, p < 0.001), and morbidity (16% versus 42%, p = 0.008). Independent predictors of DFS included prior chemotherapy (HR 5.07, 95% CI 1.85, 13.89; p = 0.002), and CC-score > 0 (HR 3.31, 95% CI 1.19, 9.41; p = 0.025), but not surgical approach. CC-score > 0 was the only independent predictor of OS (HR 10.12, 95% CI 2.16, 47.30, p = 0.003). CONCLUSIONS AND RELEVANCE: Laparoscopic CRS/HIPEC should be considered for patients with PSM with low-volume disease, including those with adenocarcinoma histology.

trial registrationClinicaltrials.gov; NCT02463877.

Indexed as

Colorectal NeoplasmsHyperthermia, InducedLaparoscopyPeritoneal NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantCombined Modality TherapyCytoreduction Surgical ProceduresFemaleHumansMaleMiddle AgedProspective StudiesRetrospective StudiesSurvival RateCytoreductive surgeryHyperthermic intraperitoneal chemotherapyMinimally-invasive surgeryPeritoneal surface malignancy

Identifiers

PMID36477643
PMCPMC10322763
OpenAlexW4310953474

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.