Evidence map›Paper›PMID 36476979›Full record

ArticleNeurobiology of disease2023

Wide-field calcium imaging reveals widespread changes in cortical functional connectivity following mild traumatic brain injury in the mouse.

Samuel W Cramer, Samuel P Haley, Laurentiu S Popa, Russell E Carter, Earl Scott, Evelyn B Flaherty, Judith Dominguez, Justin D Aronson, Luke Sabal, Daniel Surinach and 3 more

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

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  5. Biphasic acclimation for simultaneous wide-field fluorescent CaImaging neuroscience (Cambridge, Mass.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Samuel W CramerDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.
Samuel P HaleyDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Laurentiu S PopaDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Russell E CarterDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Earl ScottDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Evelyn B FlahertyDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Judith DominguezDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Justin D AronsonDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Luke SabalDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Daniel SurinachDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Clark C ChenDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.
Suhasa B KodandaramaiahDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Timothy J EbnerDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: ebner001@umn.edu.
University of Minnesota · US

Funding

Viral Innovation CoreP30DA048742 · NIDA · UNIVERSITY OF MINNESOTA · PI Mark John Thomas · 2020 to 2026
$19.0M
Miniaturized head-mounted device for pan-cortical electro-optical activity monitoringR01NS111028 · NINDS · UNIVERSITY OF MINNESOTA · PI KODANDARAMAIAH, SUHASA B, SWISHER, SARAH L · 2019 to 2023
$2.4M
Full human gene-replacement mouse models of ADRDsR33NS115089 · NINDS · UNIVERSITY OF MINNESOTA · PI EBNER, TIMOTHY J, KOOB, MICHAEL D · 2021 to 2021
$2.3M
Full human gene-replacement mouse models of ADRDsR61NS115089 · NINDS · UNIVERSITY OF MINNESOTA · PI EBNER, TIMOTHY J, KOOB, MICHAEL D · 2019 to 2019
$1.5M
NIDA NIH HHS P30 DA048742NINDS NIH HHS R01 NS111028NINDS NIH HHS R33 NS115089NINDS NIH HHS R61 NS115089
6 · The paper itself

Abstract

>2.5 million individuals in the United States suffer mild traumatic brain injuries (mTBI) annually. Mild TBI is characterized by a brief period of altered consciousness, without objective findings of anatomic injury on clinical imaging or physical deficit on examination. Nevertheless, a subset of mTBI patients experience persistent subjective symptoms and repeated mTBI can lead to quantifiable neurological deficits, suggesting that each mTBI alters neurophysiology in a deleterious manner not detected using current clinical methods. To better understand these effects, we performed mesoscopic Ca

Indexed as

Brain ConcussionAnimalsCalciumCerebral CortexMagnetic Resonance ImagingMiceCalciumCalcium imagingFunctional connectivityIn vivo optical imagingNetwork dynamicsSpatial independent component analysisTraumatic brain injury

Identifiers

PMID36476979
PMCPMC9972226
OpenAlexW4312083312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.