Evidence map›Paper›PMID 36476946›Full record

ArticleScientific reports2022

Implications of differential peroxyl radical-induced inactivation of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase for the pentose phosphate pathway.

Juan Sebastián Reyes, Eduardo Fuentes-Lemus, Juan David Figueroa, Javier Rojas, Angélica Fierro, Felipe Arenas, Per M Hägglund, Michael J Davies, Camilo López-Alarcón

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Juan Sebastián ReyesDepartamento de Química Física, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile.
Eduardo Fuentes-LemusDepartment of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Juan David FigueroaDepartamento de Química Física, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile.
Javier RojasDepartamento de Química Física, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile.
Angélica FierroDepartamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile.
Felipe ArenasDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.
Per M HägglundDepartment of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Michael J DaviesDepartment of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Camilo López-AlarcónDepartamento de Química Física, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile. clopezr@uc.cl.
Pontificia Universidad Católica de Chile · CLUniversity of Copenhagen · DKUniversidad de Santiago de Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Escherichia coli glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) are key enzymes of the pentose phosphate pathway, responsible for the NADPH production in cells. We investigated modification of both enzymes mediated by peroxyl radicals (ROO

Indexed as

Pentose Phosphate PathwayPhosphogluconate DehydrogenaseGlucoseGlucosephosphate DehydrogenaseNADPPeroxidesPhosphatesGlucoseGlucosephosphate DehydrogenaseNADPperhydroxyl radicalPeroxidesPhosphatesPhosphogluconate Dehydrogenase

Identifiers

PMID36476946
PMCPMC9729611
OpenAlexW4311578406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.