ArticleCell metabolism2022
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade.
Article in Cell metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- The gut microbiome and cancer: from tumorigenesis to therapy.Nature metabolism · 2025Review
- Microbial metabolite-driven immune reprogramming in tumor immunotherapy: mechanisms and therapeutic perspectives.Frontiers in immunology · 2025Review
- Resting CD4 regulatory T cell and neuroblastoma: A Mendelian randomization study.Pediatric discovery · 2024Article
- Gut microbiota-generated metabolites: missing puzzles to hosts' health, diseases, and aging.BMB reports · 2024Review
- Alteration of gut microbiome and correlated amino acid metabolism are associated with acute myelocytic leukemia carcinogenesis.Cancer medicine · 2023Article
- Bibliometric analysis of global research trends between gut microbiota and pancreatic cancer: from 2004 to 2023.Frontiers in microbiology · 2023Review
- The protective role of commensal gut microbes and their metabolites against bacterial pathogens.Gut microbesArticle
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tumor and gut microbiome regulate antitumor immunity and modulate responses to immune checkpoint blockade, although the mechanisms of action remain uncertain. A recent study in Science Immunology by Mirji et al. describes that the microbiota-generated metabolite trimethylamine N-oxide (TMAO) plays a critical role in mediating the effects of the microbiome on antitumor immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.