Evidence map›Paper›PMID 36476859›Full record

ArticleCell reports2022

Essential role of the mitochondrial Na

Maya Rozenfeld, Ivana Savic Azoulay, Tsipi Ben Kasus Nissim, Alexandra Stavsky, Moran Melamed, Grace Stutzmann, Michal Hershfinkel, Ora Kofman, Israel Sekler

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. The role of mitochondrial Na⁺/Ca²⁺ exchanger in brain cell aging.Journal of bioenergetics and biomembranes · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Mitochondrial CaBiomolecules · 2026
    Review
  8. Review
  9. Article
  10. Longevity, enhanced memory, and altered density of dendritic spines in hippocampal CA3 and dentate gyrus after hemizygous deletion of Pde2a in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  11. Loss of mitochondrial CaCell communication and signaling : CCS · 2024
    Article
  12. NCLX controls hepatic mitochondrial CaMolecular metabolism · 2024
    Article
  13. Targeting mitochondrial CaThe Journal of physiology · 2024
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Regulation of KInternational journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Maya RozenfeldDepartment of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Ivana Savic AzoulayDepartment of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Tsipi Ben Kasus NissimDepartment of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Alexandra StavskyDepartment of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Moran MelamedDepartment of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Grace StutzmannRosalind Franklin University of Medicine and Science, Chicago Medical School, Center for Neurodegenerative Disease and Therapeutics, Chicago, IL, USA.
Michal HershfinkelDepartment of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Ora KofmanDepartment of Psychology, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Israel SeklerDepartment of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address: sekler@bgu.ac.
Ben-Gurion University of the Negev · ILRosalind Franklin University of Medicine and Science · US

Funding

Intracellular organelle deficits driving Alzheimer's diseaseRF1AG065628 · NIA · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI SEKLER, ISRAEL, STUTZMANN, GRACE E. · 2020 to 2020
$1.7M
NIA NIH HHS RF1 AG065628
6 · The paper itself

Abstract

Impaired phosphodiesterase (PDE) function and mitochondrial Ca

Indexed as

Phosphoric Diester HydrolasesSodium-Calcium ExchangerAnimalsMiceSyndromePhosphoric Diester HydrolasesSodium-Calcium ExchangerBay 60-7550caffeineCP: Neurosciencemitochondrial Ca(2+) signalingNCLXPDE2

Identifiers

PMID36476859
PMCPMC10521900
OpenAlexW4310859843

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.