Evidence map›Paper›PMID 36476762›Full record

ArticleScientific reports2022

Replicative bypass studies of l-deoxyribonucleosides in Vitro and in E. coli cell.

Yuhe Kan, Zhaoyang Jin, Yongqi Ke, Dao Lin, Liang Yan, Li Wu, Yujian He

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yuhe Kan *School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Zhaoyang Jin *School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Yongqi KeSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Dao LinSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Liang YanSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Li WuSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China. wuli@ucas.ac.cn.
Yujian HeSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China. heyujian@ucas.ac.cn.
University of Chinese Academy of Sciences · CNPeking University · CNInner Mongolia University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L-nucleosides were the most important antiviral lead compounds because they can inhibit viral DNA polymerase and DNA synthesis of many viruses, whereas they may lead to mutations in DNA replication and cause genomic instability. In this study, we reported the replicative bypass of L-deoxynucleosides in recombinant DNA by restriction enzyme-mediated assays to examine their impact on DNA replication in vitro and in E. coli cells. The results showed that a template L-dC inhibited Taq DNA polymerase reaction, whereas it can be bypassed by Vent (exo

Indexed as

Escherichia coliTaq PolymeraseTaq Polymerase

Identifiers

PMID36476762
PMCPMC9729220
OpenAlexW4311584805

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.