Evidence map›Paper›PMID 36476475›Full record

ArticleBMC pulmonary medicine2022

Effects of airway pressure release ventilation on multi-organ injuries in severe acute respiratory distress syndrome pig models.

Aijia Ma, Bo Wang, Jiangli Cheng, Meiling Dong, Yang Li, Canzheng Wei, Yongfang Zhou, Yang Xue, Hui Gao, Lican Zhao and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 73% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Aijia Ma *Department of Critical Care Medicine, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
Bo Wang *Department of Critical Care Medicine, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
Jiangli ChengDepartment of Critical Care Medicine, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
Meiling DongDepartment of Critical Care Medicine, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
Yang LiDepartment of Critical Care Medicine, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
Canzheng WeiDepartment of Critical Care Medicine, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
Yongfang ZhouDepartment of Critical Care Medicine, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
Yang XueDepartment of Critical Care Medicine, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
Hui GaoDepartment of Nursing, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
Lican ZhaoDepartment of Nursing, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
Siyu LiDepartment of Nursing, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
Yiwei QinDepartment of Critical Care Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China.
Mengni ZhangDepartment of Pathology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
Qin WuDepartment of Critical Care Medicine, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
Jing YangDepartment of Critical Care Medicine, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan Province, China. yjingscu@163.com.
Yan KangDepartment of Critical Care Medicine, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan Province, China. Kangyan@scu.edu.cn.
West China Hospital of Sichuan University · CNSichuan University · CNFirst Affiliated Hospital of Chengdu Medical College · CN

Funding

1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University ZYGD18020National Natural Science Foundation of China 81873929
6 · The paper itself

Abstract

backgroundExtra-pulmonary multi-organ failure in patients with severe acute respiratory distress syndrome (ARDS) is a major cause of high mortality. Our purpose is to assess whether airway pressure release ventilation (APRV) causes more multi-organ damage than low tidal volume ventilation (LTV).

methodsTwenty one pigs were randomized into control group (n = 3), ARDS group (n = 3), LTV group (n = 8) and APRV group (n = 7). Severe ARDS model was induced by repeated bronchial saline lavages. Pigs were ventilated and monitored continuously for 48 h. Respiratory data, hemodynamic data, serum inflammatory cytokines were collected throughout the study. Histological injury and apoptosis were assessed by two pathologists.

resultsAfter severe ARDS modeling, pigs in ARDS, LTV and APRV groups experienced significant hypoxemia and reduced lung static compliance (C

conclusionIn conclusion, in the experimental pig models of severe ARDS induced by repetitive saline lavage, APRV improved lung compliance with reduced lung injury of middle and lower lobes, and did not demonstrate more extra-pulmonary organ injuries as compared with LTV.

Indexed as

Continuous Positive Airway PressureRespiratory Distress SyndromeAnimalsApoptosisSwineAcute respiratory distress syndromeAirway pressure release ventilationLow tidal volumeMechanical ventilationMulti-organ dysfunction syndrome

Identifiers

PMID36476475
PMCPMC9730639
OpenAlexW4311581074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.