ArticleNature communications2022
The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Developmental Scarcity Induces Sex Differences in Social Recognition and CA2 Perineuronal Nets.eNeuro · 2026Article
- Limited sucrose intake produces subregion-specific remodeling of perineuronal nets in the medial prefrontal cortex.Brain structure & function · 2026Article
- Different early-life adversity paradigms have disparate effects on maternal care, neuronal activation, and social behavior in developing mice.Neurobiology of stress · 2026Article
- Developmental scarcity induces sex differences in social recognition and CA2 perineuronal nets.bioRxiv : the preprint server for biology · 2026Article
- Experience-dependent maturation of somatosensory parvalbumin interneurons during social development in prairie voles.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Early life social isolation stress and pain vulnerability: unraveling neuroimmune mechanisms and central sensitization.Frontiers in pharmacology · 2026Review
- Estrogenic regulation of perineuronal nets in the mouse insular cortex and hippocampus.Neuropharmacology · 2025Article
- Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Sex-Specific Effects of Experience With Pups on Perineuronal Net Expression in the Biparental California Mouse (Peromyscus californicus).The Journal of comparative neurology · 2025Article
- Estrogenic regulation of hippocampal inhibitory system across lifespan.Journal of neuroendocrinology · 2025Review
- Neonatal estradiol and early adversity interact to modify basolateral amygdala morphology and adult behavior in female rats.Journal of neuroendocrinology · 2025Article
- Sex-specific characterization of aortic function and inflammation in a new diet-induced mouse model of metabolic syndrome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism.Communications biology · 2024Article
- Social and nonsocial environmental loss have differential effects on ventral hippocampus-dependent behavior and inhibitory synaptic markers in adult male mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Modulation of stress-, pain-, and alcohol-related behaviors by perineuronal nets.Neurobiology of stress · 2024Article
- Sex- and cycle-dependent changes in spine density and size in hippocampal CA2 neurons.Scientific reports · 2024Article
- Developmental and adult stress: effects of steroids and neurosteroids.Stress (Amsterdam, Netherlands) · 2024Review
- Shifts in naturalistic behaviors induced by early social isolation stress are associated with adult binge-like eating in female rats.Frontiers in behavioral neuroscience · 2024Article
- Sex differences in avoidance behavior and cued threat memory dynamics in mice: Interactions between estrous cycle and genetic background.Hormones and behavior · 2023Article
- Sexually dimorphic role for insular perineuronal nets in aversion-resistant alcohol consumption.Frontiers in psychiatry · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Early-life adversity (ELA) increases the likelihood of neuropsychiatric diagnoses, which are more prevalent in women than men. Since changes in reproductive hormone levels can also increase the probability of anxiety disorders in women, we examined the effects of ELA on adult female mice across the estrous cycle. We found that during diestrus, when progesterone levels are relatively high, ELA mice exhibit increased avoidance behavior and increased theta oscillation power in the ventral hippocampus (vHIP). We also found that diestrus ELA mice had higher levels of progesterone and lower levels of allopregnanolone, a neurosteroid metabolite of progesterone, in the vHIP compared with control-reared mice. Progesterone receptor antagonism normalized avoidance behavior in ELA mice, while treatment with a negative allosteric modulator of allopregnanolone promoted avoidance behavior in control mice. These results suggest that altered vHIP progesterone and allopregnanolone signaling during diestrus increases avoidance behavior in ELA mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.