Evidence map›Paper›PMID 36476152›Full record

Trial reportClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Does Intraoperative Fibrinogen Affect Blood Loss or Transfusion Practice After Aortic Arch Surgery: A Prematurely Ended Randomized Trial.

Eline A Vlot, Christian M Hackeng, Stijn J A Aper, Uday Sonker, Robin H Heijmen, Eric P A van Dongen, Peter G Noordzij

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Eline A VlotDepartment of Anesthesia, Intensive Care and Pain Medicine, 6028St. Antonius Hospital, Nieuwegein, Netherlands.ORCID 0000-0002-3538-8880
Christian M HackengDepartment of Clinical Chemistry, 6028St. Antonius Hospital, Nieuwegein, Netherlands.
Stijn J A AperDepartment of Clinical Chemistry, 6028St. Antonius Hospital, Nieuwegein, Netherlands.
Uday SonkerDepartment of Cardiac Surgery, 6028St. Antonius Hospital, Nieuwegein, Netherlands.
Robin H HeijmenDepartment of Cardiac Surgery, 6028St. Antonius Hospital, Nieuwegein, Netherlands.
Eric P A van DongenDepartment of Anesthesia, Intensive Care and Pain Medicine, 6028St. Antonius Hospital, Nieuwegein, Netherlands.
Peter G NoordzijDepartment of Anesthesia, Intensive Care and Pain Medicine, 6028St. Antonius Hospital, Nieuwegein, Netherlands.
St. Antonius Ziekenhuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular surgery is often complicated by significant bleeding due to perioperative coagulopathy. The effectiveness of treatment with fibrinogen concentrate to reduce the perioperative blood transfusion rate after thoracic aortic replacement surgery in prior studies has shown conflicting results. Therefore, we conducted a double-blind randomized controlled trial to investigate if a single dose of intraoperative fibrinogen administration reduced blood loss and allogeneic transfusion rate after elective surgery for thoracic arch aneurysm with deep hypothermic circulatory arrest. Twenty patients were randomized to fibrinogen concentrate (

Indexed as

Aorta, ThoracicFibrinogenBlood TransfusionHumansPostoperative HemorrhageProspective StudiesThrombinFibrinogenThrombinfibrinogenhemostasisthoracic aorta surgerythrombin generationthromboelastographytransfusion

Identifiers

PMID36476152
PMCPMC9742581
OpenAlexW4311573456

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.