Evidence map›Paper›PMID 36475947›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Bioengineered peptibodies as blockers of ion channels.

Bojjibabu Chidipi, Mengmeng Chang, Meng Cui, Obada Abou-Assali, Michelle Reiser, Sergii Pshenychnyi, Diomedes E Logothetis, Michael N Teng, Sami F Noujaim

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Bojjibabu ChidipiDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.ORCID 0000-0003-4107-1668
Mengmeng ChangDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.
Meng CuiDepartment of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Center for Drug Discovery, Northeastern University, Boston, MA 02115.ORCID 0000-0002-3895-135X
Obada Abou-AssaliDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.ORCID 0000-0002-0021-8865
Michelle ReiserDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.
Sergii PshenychnyiChemistry for Life Processes Institute, Northwestern University, Evanston, IL 60208.
Diomedes E LogothetisDepartment of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Center for Drug Discovery, Northeastern University, Boston, MA 02115.ORCID 0000-0002-0576-884X
Michael N TengDepartment of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.
Sami F NoujaimDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.ORCID 0000-0002-0078-3477
University of South Florida · USNortheastern University · USNorthwestern University · US

Funding

Structural Determinants of PIP2 RegulationR01HL059949 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Leigh Daniel Plant · 1998 to 2026
$11.6M
Bioengineered peptibodies as antiarrhythmic therapy in atrial fibrillationR21HL138064 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI NOUJAIM, SAMI FOUAD · 2017 to 2018
$411k
NHLBI NIH HHS R01 HL059949NHLBI NIH HHS R21 HL138064
6 · The paper itself

Abstract

We engineered and produced an ion channel blocking peptibody, that targets the acetylcholine-activated inwardly rectifying potassium current (I

Indexed as

PotassiumAnimalsBeesHumansMicePotassiumIKAChpeptibodypotassium channelsprotein engineering

Identifiers

PMID36475947
PMCPMC9897444
OpenAlexW4311171055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.