Trial reportScience translational medicine2022
A randomized controlled trial showing safety and efficacy of a whole sporozoite vaccine against endemic malaria.
Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03989102 (Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
9.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Malaria Transmission Season in Healthy African Adult Women of Childbearing Potential in Mali
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Effectiveness of interventions to improve vaccine efficacy: a systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- Safety, tolerability and immunogenicity of a condensed, multi-dose prime regimen of PfSPZ Vaccine for the prevention of Plasmodium falciparum malaria infection.Malaria journal · 2025Trial
- Safety and efficacy of PfSPZ Vaccine against malaria in healthy adults and women anticipating pregnancy in Mali: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials.The Lancet. Infectious diseases · 2024Trial
- Implementation of a Randomized, Placebo-Controlled Trial of Live Attenuated Malaria Sporozoite Vaccines in an Indonesian Military Study Population.The American journal of tropical medicine and hygiene · 2024Trial
- Safety and protective efficacy of PfSPZ Vaccine administered to HIV-negative and -positive Tanzanian adults.The Journal of clinical investigation · 2024Trial
- Safety and Immunogenicity of Radiation-Attenuated PfSPZ Vaccine in Equatoguinean Infants, Children, and Adults.The American journal of tropical medicine and hygiene · 2023Trial
- Combining seasonal malaria chemoprevention with novel therapeutics for malaria prevention: a mathematical modelling study.PLoS computational biology · 2026Article
- Better late than never: defining the ideal vaccine that targets pre-erythrocytic malaria infection.EMBO molecular medicine · 2025Article
- Assessment of Health Status and Creation of a Registry of Potential Research Participants Aged 1.5 to 50 Years on Bioko Island, Equatorial Guinea.The American journal of tropical medicine and hygiene · 2025Article
- Malaria Vaccines and Global Equity: A Scoping Review of Current Progress and Future Directions.Biomedicines · 2025Review
- Protective targets of PfSPZ vaccines identified from whole-genome sieve analysis of isolates from malaria vaccine efficacy trials in West Africa.medRxiv : the preprint server for health sciences · 2025Article
- Malaria: Factors affecting disease severity, immune evasion mechanisms, and reversal of immune inhibition to enhance vaccine efficacy.PLoS pathogens · 2025Review
- Malaria vaccines: a new era of prevention and control.Nature reviews. Microbiology · 2024Review
- Whole-sporozoite malaria vaccines: where we are, where we are going.EMBO molecular medicine · 2024Review
- Experimental vaccination by single dose sporozoite injection of blood-stage attenuated malaria parasites.EMBO molecular medicine · 2024Article
- Vaccines and monoclonal antibodies: new tools for malaria control.Clinical microbiology reviews · 2024Review
- Ageing of Plasmodium falciparum malaria sporozoites alters their motility, infectivity and reduces immune activation in vitro.Malaria journal · 2024Article
- A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion.EMBO molecular medicine · 2024Article
- Profiling the antibody response of humans protected by immunization with Plasmodium vivax radiation-attenuated sporozoites.Scientific reports · 2024Article
- Can incorporating genotyping data into efficacy estimators improve efficiency of early phase malaria vaccine trials?Malaria journal · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 5 institutions in 2 countries.
Sodiomon B SirimaGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.ORCID 0000-0002-0972-4211
Alphonse OuédraogoGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.
Alfred B TionoGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.ORCID 0000-0002-5104-3946
Jean M KaboréGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.ORCID 0000-0002-8560-2507
Edith C BougoumaGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.ORCID 0000-0001-6384-118X
Maurice S OuattaraGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.ORCID 0000-0002-4329-0445
Désiré KargougouCentre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso.ORCID 0000-0002-5010-9894
Amidou DiarraGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.
Noelie HenryGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.
Issa N OuédraogoGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.ORCID 0000-0003-3051-3600
Peter F BillingsleySanaria Inc., Rockville, MD, USA.ORCID 0000-0003-1142-4813
Anita ManojSanaria Inc., Rockville, MD, USA.
Yonas AbebeSanaria Inc., Rockville, MD, USA.
Natasha KcSanaria Inc., Rockville, MD, USA.
Adam RubenSanaria Inc., Rockville, MD, USA.
Thomas L RichieSanaria Inc., Rockville, MD, USA.ORCID 0000-0002-2946-5456
Eric R JamesSanaria Inc., Rockville, MD, USA.
Sudhaunshu JoshiCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-2375-3086
Biraj ShresthaCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Kathy StraussCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-0854-0090
Kirsten E LykeCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-4966-0830
Christopher V PloweCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-0045-9888
Gail E PotterEmmes Company LLC, Rockville, MD, USA.ORCID 0000-0001-6667-6992
Catherine CoxEmmes Company LLC, Rockville, MD, USA.ORCID 0000-0002-5523-6956
Walter JonesParasitic and International Programs Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8955-2877
B Kim Lee SimSanaria Inc., Rockville, MD, USA.ORCID 0000-0002-8598-8905
Stephen L HoffmanSanaria Inc., Rockville, MD, USA.ORCID 0000-0002-0700-9505
Matthew B LaurensCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-3874-581X
Centre National de Recherche et de Formation sur le Paludisme · BFSanaria · USUniversity of Maryland, Baltimore · USEmmes (United States) · USNational Institute of Allergy and Infectious Diseases · US
Funding
Plasmodium Falciparum Whole Sporozoite Malaria VaccineR44AI055229 · NIAID · SANARIA, INC. · PI HOFFMAN, STEPHEN LEV · 2005 to 2015
$10.0MSafety and efficacy of PfSPZ malaria vaccine in malaria-exposed adultsU01AI112367 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LAURENS, MATTHEW BRENT · 2015 to 2018
$2.8MNIAID NIH HHS R44 AI055229NIAID NIH HHS U01 AI112367
Abstract
A highly effective malaria vaccine remains elusive despite decades of research.
Indexed as
SporozoitesVaccinesAnimalsHumansVaccines
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT03989102ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.