Evidence map›Paper›PMID 36475869›Full record

ArticleAmerican journal of physiology. Renal physiology2023

Brown-Norway chromosome 1 mitigates the upregulation of proinflammatory pathways in mTAL cells and subsequent age-related CKD in Dahl SS/JrHsdMcwi rats.

Jacqueline M Chivers, Shannon A Whiles, Conor B Miles, Brianna E Biederman, Megan F Ellison, Connor W Lovingood, Marie H Wright, Donald B Hoover, Muhammad A Raafey, George A Youngberg and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 1 country.

Jacqueline M ChiversDepartment of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee.ORCID 0000-0001-8346-3278
Shannon A WhilesDepartment of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee.ORCID 0000-0002-0740-4134
Conor B MilesDepartment of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee.
Brianna E BiedermanDepartment of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee.
Megan F EllisonDepartment of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee.
Connor W LovingoodDepartment of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee.
Marie H WrightDepartment of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee.
Donald B HooverDepartment of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee.ORCID 0000-0002-0845-2488
Muhammad A RaafeyDepartment of Pathology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
George A YoungbergDepartment of Pathology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
Manjeri A VenkatachalamDepartment of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Nadezhda N ZheleznovaDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Chun YangDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Pengyuan LiuDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Alison J KriegelDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0002-3961-9893
Allen W CowleyDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Paul M O'ConnorDepartment of Physiology, Augusta University, Augusta, Georgia.
Maria M PickenDepartment of Pathology, Loyola University Medical Center, Maywood, Illinois.ORCID 0000-0002-8065-6178
Aaron J PolichnowskiDepartment of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee.ORCID 0000-0003-0347-663X
East Tennessee State University · USMedical College of Wisconsin · USAugusta University · USLoyola University Medical Center · USThe University of Texas Health Science Center at San Antonio · US

Funding

Therapeutic Effects of mTOR Inhibition in Salt-Sensitive HypertensionP01HL116264 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MATTSON, DAVID L. · 2013 to 2021
$18.7M
Toll-like receptor 9 activation by mitochondrial DNA causes vascular injury in hypertensionP01HL134604 · NHLBI · AUGUSTA UNIVERSITY · PI BRANDS, MICHAEL W. · 2017 to 2021
$9.4M
High Salt Remodels Renal Cortical and Proximal Tubular Metabolism: Metabolic Fuels, Oxidative Stress, and HypertensionR01HL151587 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Allen W Cowley, Ranjan K Dash · 2021 to 2026
$3.7M
miRNA Mediated Cross-Talk in CRS4: The Role of the miR-21-5p/PPAR-Alpha PathwayR01HL128332 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI KRIEGEL, ALISON J · 2016 to 2020
$1.9M
Mitochondrial Recovery after Acute Kidney Injury Needs Ribonucleotide ReductaseR01DK119693 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI VENKATACHALAM, MANJERI A · 2020 to 2022
$696k
Hemodynamic mechanisms of impaired recovery and progression of renal disease following AKI in preexisting CKD statesR15HL154067 · NHLBI · EAST TENNESSEE STATE UNIVERSITY · PI POLICHNOWSKI, AARON JAMES · 2020 to 2020
$444k
American Heart Association (AHA) 17AIREA33660433American Physiological Society (APS) Dean Franklin AwardAmerican Physiological Society (APS) Lazaro Mandel AwardAmerican Society of Nephrology (ASN)East Tennessee State University (ETSU)HHS | National Institutes of Health (NIH) C06RR0306551HHS | National Institutes of Health (NIH) P01-HL116264HHS | National Institutes of Health (NIH) P01-HL134604HHS | National Institutes of Health (NIH) R01-HL128332HHS | National Institutes of Health (NIH) R01-HL151587HHS | National Institutes of Health (NIH) R15-HL154067NHLBI NIH HHS P01 HL116264NHLBI NIH HHS P01 HL134604NHLBI NIH HHS R01 HL128332NHLBI NIH HHS R01 HL151587NHLBI NIH HHS R15 HL154067NIDDK NIH HHS R01 DK119693
6 · The paper itself

Abstract

Chronic kidney disease (CKD) has a strong genetic component; however, the underlying pathways are not well understood. Dahl salt-sensitive (SS)/Jr rats spontaneously develop CKD with age and are used to investigate the genetic determinants of CKD. However, there are currently several genetically diverse Dahl SS rats maintained at various institutions and the extent to which some exhibit age-related CKD is unclear. We assessed glomerulosclerosis (GS) and tubulointerstitial fibrosis (TIF) in 3- and 6-mo-old male and female SS/JrHsdMcwi, BN/NHsd/Mcwi [Brown-Norway (BN)], and consomic SS-Chr 1

Indexed as

HypertensionKidney DiseasesAnimalsChromosomes, Human, Pair 1FemaleHumansMaleRatsRats, Inbred BNRats, Inbred DahlSodium ChlorideSodium Chloride, DietaryUp-RegulationSodium ChlorideSodium Chloride, Dietarychronic kidney diseasechronic progressive nephropathyconsomic SS.BN1 ratDahl salt-sensitive rathypertension

Identifiers

PMID36475869
PMCPMC9886360
OpenAlexW4310964740

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.