Evidence map›Paper›PMID 36475838›Full record

ArticleMicrobiology spectrum2023

Host Genetics and Environment Shape the Composition of the Gastrointestinal Microbiome in Nonhuman Primates.

Jacob K Flynn, Alexandra M Ortiz, Richard Herbert, Jason M Brenchley

Abstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jacob K FlynnBarrier Immunity Section, Lab of Viral Diseases, NIAID, NIH, Bethesda, Maryland, USA.
Alexandra M OrtizBarrier Immunity Section, Lab of Viral Diseases, NIAID, NIH, Bethesda, Maryland, USA.
Richard HerbertComparative Medicine Branch, NIAID, NIH, Bethesda, Maryland, USA.
Jason M BrenchleyBarrier Immunity Section, Lab of Viral Diseases, NIAID, NIH, Bethesda, Maryland, USA.ORCID 0000-0001-8357-2984

Funding

Mechanisms of Immune Activation and Disease Progression in Animal ModelsZIAAI001029 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BRENCHLEY, JASON · 2009 to 2025
$28.2M
Intramural NIH HHS ZIA AI001029
6 · The paper itself

Abstract

The bacterial component of the gastrointestinal tract microbiome is comprised of hundreds of species, the majority of which live in symbiosis with the host. The bacterial microbiome is influenced by host diet and disease history, and host genetics may additionally play a role. To understand the degree to which host genetics shapes the gastrointestinal tract microbiome, we studied fecal microbiomes in 4 species of nonhuman primates (NHPs) held in separate facilities but fed the same base diet. These animals include Chlorocebus pygerythrus, Chlorocebus sabaeus, Macaca mulatta, and Macaca nemestrina. We also followed gastrointestinal tract microbiome composition in 20 Macaca mulatta (rhesus macaques [RMs]) as they transitioned from an outdoor to indoor environment and compared 6 Chlorocebus pygerythrus monkeys that made the outdoor to indoor transition to their 9 captive-born offspring. We found that genetics can influence microbiome composition, with animals of different genera (

Indexed as

Gastrointestinal MicrobiomeMicrobiotaAnimalsChlorocebus aethiopsDietMacaca mulattaPhylogenyRNA, Ribosomal, 16SRNA, Ribosomal, 16SGI tract microbiomehost geneticsnonhuman primates

Identifiers

PMID36475838
PMCPMC9927375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.