Evidence map›Paper›PMID 36475663›Full record

ArticleJournal of the American Chemical Society2022

Systemic Delivery of Divalent Europium from Ligand Screening with Implications to Direct Imaging of Hypoxia.

Md Mamunur Rashid, Brooke A Corbin, Pavan Jella, Caitlyn J Ortiz, Md Abul Hassan Samee, Robia G Pautler, Matthew J Allen

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Single Molecule EuJournal of the American Chemical Society · 2026
    Article
  3. Article
  4. Article
  5. Reversible Enzymatic Switching of the Oxidation State of a EuJournal of the American Chemical Society · 2025
    Article
  6. Hypoxia Imaging as a Radiomics Signature in Tumors Using NovelbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Toward quantification of hypoxia using fluorinated EuProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Md Mamunur RashidDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan48202, United States.
Brooke A CorbinDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan48202, United States.
Pavan JellaDepartment of Radiology, Wayne State University, Detroit, Michigan48201, United States.
Caitlyn J OrtizDepartment of Integrative Physiology, Baylor College of Medicine, Houston, Texas77030, United States.
Md Abul Hassan SameeDepartment of Integrative Physiology, Baylor College of Medicine, Houston, Texas77030, United States.ORCID 0000-0002-7472-1156
Robia G PautlerDepartment of Integrative Physiology, Baylor College of Medicine, Houston, Texas77030, United States.
Matthew J AllenDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan48202, United States.ORCID 0000-0002-6868-8759
Wayne State University · USBaylor College of Medicine · US

Funding

Tailoring Structures of Sulfated Oligosaccharides for Modulating Heparanase ActivityR01GM098285 · NIGMS · WAYNE STATE UNIVERSITY · PI NGUYEN, HIEN M · 2012 to 2022
$3.5M
Library Synthesis and Screening of Eu(II)-Based Contrast AgentsR01EB027103 · NIBIB · WAYNE STATE UNIVERSITY · PI ALLEN, MATTHEW J · 2019 to 2022
$1.4M
Synthesis and characterization of linked Eu(II)-containing complexes and paramagnetic shift reagents for hypoxia imagingF31CA247600 · NCI · WAYNE STATE UNIVERSITY · PI CORBIN, BROOKE ANNE · 2020 to 2021
$60k
NCI NIH HHS F31 CA247600NIBIB NIH HHS R01 EB027103NIGMS NIH HHS R01 GM098285
6 · The paper itself

Abstract

Hypoxia is a hallmark of many diseases, including cancer, arthritis, heart and kidney diseases, and diabetes, and it is often associated with disease aggressiveness and poor prognosis. Consequently, there is a critical need for imaging hypoxia in a noninvasive and direct way to diagnose, stage, and monitor the treatment and development of new therapies for these diseases. Eu-containing contrast agents for magnetic resonance imaging have demonstrated potential for in vivo imaging of hypoxia via changes in metal oxidation state from +2 to +3, but rapid oxidation in blood limits Eu

Indexed as

EuropiumLanthanoid Series ElementsContrast MediaLigandsMagnetic Resonance ImagingContrast MediaEuropiumLanthanoid Series ElementsLigands

Identifiers

PMID36475663
PMCPMC9782726
OpenAlexW4312194962

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.