ArticleJournal of the Royal Society, Interface2022
Ultrastructural and kinetic evidence support that thick filaments slide through the Z-disc.
Article in Journal of the Royal Society, Interface, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Reproducibility of smooth muscle mechanical properties in consecutive stretch and activation protocols.Pflugers Archiv : European journal of physiology · 2025Article
- Feats of supercontractile strength: functional convergence of supercontracting muscle properties among hyoid musculature in chameleons.Proceedings. Biological sciences · 2025Article
- The effect of muscle ultrastructure on the force, displacement and work capacity of skeletal muscle.Journal of the Royal Society, Interface · 2024Article
- Structurally motivated models to explain the muscle's force-length relationship.Biophysical journal · 2023Article
- Sarcomere mechanics in the double-actin-overlap zone.Biophysical journal · 2023Article
- Ultrastructural and kinetic evidence support that thick filaments slide through the Z-disc.Journal of the Royal Society, Interface · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How myofilaments operate at short mammalian skeletal muscle lengths is unknown. A common assumption is that thick (myosin-containing) filaments get compressed at the Z-disc. We provide ultrastructural evidence of sarcomeres contracting down to 0.44 µm-approximately a quarter of thick filament resting length-in long-lasting contractions while apparently keeping a regular, parallel thick filament arrangement. Sarcomeres produced force at such extremely short lengths. Furthermore, sarcomeres adopted a bimodal length distribution with both modes below lengths where sarcomeres are expected to generate force in classic force-length measurements. Mammalian fibres did not restore resting length but remained short after deactivation, as previously reported for amphibian fibres, and showed increased forces during passive re-elongation. These findings are incompatible with viscoelastic thick filament compression but agree with predictions of a model incorporating thick filament sliding through the Z-disc. This more coherent picture of mechanical mammalian skeletal fibre functioning opens new perspectives on muscle physiology.
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