Evidence map›Paper›PMID 36475388›Full record

ArticleJournal of the American Geriatrics Society2023

Impact of persistent pain on function, cognition, and well-being of older adults.

Christine Seel Ritchie, Kanan Patel, John Boscardin, Christine Miaskowski, Ana-Maria Vranceanu, Elizabeth Whitlock, Alexander Smith

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

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  14. Factors Influencing Outcomes of a Telehealth-Based Physical Activity Program in Older Veterans Postdischarge.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2025
    Article
  15. Do Physical Activities Prevent the Occurrence of Bothersome Pain?Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025
    Article
  16. Article
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  20. Editorial: Pain and relationships.Frontiers in pain research (Lausanne, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christine Seel RitchieDepartment of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-4881-9416
Kanan PatelDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
John BoscardinDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Christine MiaskowskiDepartment of Physiological Nursing, School of Nursing, University of California San Francisco, San Francisco, CA, USA.
Ana-Maria VranceanuDeparment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Elizabeth WhitlockDepartment of Anesthesia, University of California San Francisco, San Francisco, CA, USA.
Alexander SmithDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USHarvard University · US

Funding

VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 2013 to 2026
$19.9M
Unnecessary and Harmful Medication Use in Older Adults with DementiaP01AG066605 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KENNETH E. COVINSKY, R. Sean Morrison · 2020 to 2026
$17.7M
NIA NIH HHS P01 AG066605NIA NIH HHS P01AG066605NIA NIH HHS P30 AG044281NIA NIH HHS P30AG044281
6 · The paper itself

Abstract

backgroundWe sought to determine the population-level associations between persistent pain and subsequent changes in physical function, cognitive function, and well-being, outcomes important to older adults.

methodsWe used data from National Health Aging Trends Study (NHATS) of community-dwelling Medicare beneficiaries age 65+ from 2011 to 2019. We defined "persistent pain" as being bothered by pain in the last month in both the 2011and 2012 interviews and "intermittent" pain including those reporting bothersome pain in one interview only. We used competing risks regression to estimate the association between persistent pain and the development of clinically meaningful declines in physical function, cognitive function, and well-being, adjusting for age, sex, race, education, and marital status at baseline.

resultsOf the 5589 eligible NHATS participants, 38.7% reported persistent pain and 27.8% reported intermittent pain. Over one-third described pain in five or more sites. Over the subsequent 7 years, participants with persistent pain were more likely to experience declines in physical function (64% persistent pain, 59% intermittent pain, 57% no bothersome pain; aHR 1.14, 95% CI 1.05-1.23) and well-being (48% persistent pain, 45% intermittent pain, 44% no bothersome pain; aHR 1.11, 95% CI 1.01-1.21), but were not more likely to experience cognitive decline (25% persistent pain, 24% intermittent pain, 23% no bothersome pain; aHR 1.02, 95% CI 0.90-1.16).

conclusionsPersistent pain is common in older adults and occurs in multiple body sites. Persistent pain contributes to meaningful declines in physical function and well-being over 7 years and warrants proactive interventions to mitigate pain.

Indexed as

Chronic PainMedicareAgedAgingCognitionEducational StatusHumansUnited Statesagingchronic painpersistent painphysical functionwell-being

Identifiers

PMID36475388
PMCPMC9871006
OpenAlexW4310963098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.