SynthesisThe American journal of psychiatry2023
In Search of Biomarkers to Guide Interventions in Autism Spectrum Disorder: A Systematic Review.
Abstract readSystematic ReviewMeta-Analysis
In one paragraph
Synthesis in The American journal of psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Potential contribution of age-related and methodological factors to limited reproducibility in autism spectrum disorder blood miRNA biomarker studies: an exploratory meta-analysis.Scientific reports · 2026Pooled it
- Prevalences of Anorexia, Autism, and Schizophrenia, Are Strongly Associated With Average Annual Temperatures: Systematic Review and Linear Regression Analysis.Brain and behavior · 2025Pooled it
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Pooled it
- Comparison of clinical efficacy and gut microbiota characteristics in children with ASD treated with fecal microbiota transplantation and ketogenic diet.BMC psychiatry · 2026Trial
- A single-blind active-control randomized controlled trial of group-based social competence intervention.Scientific reports · 2025Trial
- Mapping the knowledge structure and emerging trends of blood-based biomarkers in autism spectrum disorder: A bibliometric analysis (2016-2026).IBRO neuroscience reports · 2026Article
- Classification of neurodevelopmental disorders and typical development using deep learning and a portable patch-type electroencephalography device.Neuroimage. Reports · 2026Article
- Autism spectrum disorder across the lifespan: Dynamic symptom trajectories and multidimensional support framework.Molecular psychiatry · 2026Review
- Machine learning model to identify gut microbiome-derived metabolites as potential biomarkers of autism spectrum disorder: a pilot study.BMC psychiatry · 2026Article
- Child and adolescent psychiatry: challenges, solutions, opportunities, and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Spatial transcriptomics implicates the thalamus and cortex in autism and schizophrenia.bioRxiv : the preprint server for biology · 2026Article
- Novel Abstract Screening Algorithm Using Delphi-Inspired Large Language Model Consensus for Systematic Reviews in Psychiatry: Nouvel algorithme de sélection des résumés utilisant un consensus issu d'un grand modèle de langage inspiré de la méthode Delphi pour les revues systématiques en psychiatrie.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2026Article
- Mesenchymal stem/stromal cell-based therapies for autism spectrum disorder: emerging evidence and clinical prospects.Journal of translational medicine · 2026Review
- μ Opioid Modulation of Sensorimotor Functional Connectivity in Autism: Insights From a Pharmacological Neuroimaging Investigation Using Tianeptine.Biological psychiatry global open science · 2026Article
- The association between autism spectrum disorder and congenital malformations: a population-based nested case-control study.Molecular psychiatry · 2026Article
- Using EEG and Eye Tracking to Evaluate an Emotion Recognition iPad App for Autistic Children.Clinical EEG and neuroscience · 2026Article
- Environmental metals, prostaglandin pathways, and immune-mediated neuroinflammation in autism spectrum disorder: A secondary analysis of peripheral biomarker studies.Metabolic brain disease · 2026Article
- Efficacy, safety, and tolerability of arbaclofen in Autistic children and adolescents, the AIMS-2-TRIALS-CT1: a randomized, double-blind, placebo-controlled phase II trial.EClinicalMedicine · 2026Article
- Cell death-associated genes as novel diagnostic biomarkers for autism spectrum disorder.Apoptosis : an international journal on programmed cell death · 2026Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Mara ParelladaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid (Parellada, Andreu-Bernabeu, Burdeus, San José Cáceres, Urbiola); CIBERSAM, Spain (Parellada, Burdeus, San José Cáceres); School of Medicine, Universidad Complutense, Madrid (Parellada); Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, and Butler Hospital, Providence, R.I. (Carpenter); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Mulva Clinic for the Neurosciences, Institute of Early Life Adversity Research, Dell Medical School, University of Texas at Austin (Nemeroff); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford (Rodriguez); Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco (State, Sanders).
Álvaro Andreu-BernabeuDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid (Parellada, Andreu-Bernabeu, Burdeus, San José Cáceres, Urbiola); CIBERSAM, Spain (Parellada, Burdeus, San José Cáceres); School of Medicine, Universidad Complutense, Madrid (Parellada); Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, and Butler Hospital, Providence, R.I. (Carpenter); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Mulva Clinic for the Neurosciences, Institute of Early Life Adversity Research, Dell Medical School, University of Texas at Austin (Nemeroff); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford (Rodriguez); Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco (State, Sanders).
Mónica BurdeusDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid (Parellada, Andreu-Bernabeu, Burdeus, San José Cáceres, Urbiola); CIBERSAM, Spain (Parellada, Burdeus, San José Cáceres); School of Medicine, Universidad Complutense, Madrid (Parellada); Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, and Butler Hospital, Providence, R.I. (Carpenter); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Mulva Clinic for the Neurosciences, Institute of Early Life Adversity Research, Dell Medical School, University of Texas at Austin (Nemeroff); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford (Rodriguez); Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco (State, Sanders).
Antonia San José CáceresDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid (Parellada, Andreu-Bernabeu, Burdeus, San José Cáceres, Urbiola); CIBERSAM, Spain (Parellada, Burdeus, San José Cáceres); School of Medicine, Universidad Complutense, Madrid (Parellada); Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, and Butler Hospital, Providence, R.I. (Carpenter); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Mulva Clinic for the Neurosciences, Institute of Early Life Adversity Research, Dell Medical School, University of Texas at Austin (Nemeroff); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford (Rodriguez); Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco (State, Sanders).
Elena UrbiolaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid (Parellada, Andreu-Bernabeu, Burdeus, San José Cáceres, Urbiola); CIBERSAM, Spain (Parellada, Burdeus, San José Cáceres); School of Medicine, Universidad Complutense, Madrid (Parellada); Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, and Butler Hospital, Providence, R.I. (Carpenter); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Mulva Clinic for the Neurosciences, Institute of Early Life Adversity Research, Dell Medical School, University of Texas at Austin (Nemeroff); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford (Rodriguez); Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco (State, Sanders).
Linda L CarpenterDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid (Parellada, Andreu-Bernabeu, Burdeus, San José Cáceres, Urbiola); CIBERSAM, Spain (Parellada, Burdeus, San José Cáceres); School of Medicine, Universidad Complutense, Madrid (Parellada); Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, and Butler Hospital, Providence, R.I. (Carpenter); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Mulva Clinic for the Neurosciences, Institute of Early Life Adversity Research, Dell Medical School, University of Texas at Austin (Nemeroff); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford (Rodriguez); Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco (State, Sanders).
Nina V KraguljacDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid (Parellada, Andreu-Bernabeu, Burdeus, San José Cáceres, Urbiola); CIBERSAM, Spain (Parellada, Burdeus, San José Cáceres); School of Medicine, Universidad Complutense, Madrid (Parellada); Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, and Butler Hospital, Providence, R.I. (Carpenter); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Mulva Clinic for the Neurosciences, Institute of Early Life Adversity Research, Dell Medical School, University of Texas at Austin (Nemeroff); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford (Rodriguez); Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco (State, Sanders).
William M McDonaldDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid (Parellada, Andreu-Bernabeu, Burdeus, San José Cáceres, Urbiola); CIBERSAM, Spain (Parellada, Burdeus, San José Cáceres); School of Medicine, Universidad Complutense, Madrid (Parellada); Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, and Butler Hospital, Providence, R.I. (Carpenter); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Mulva Clinic for the Neurosciences, Institute of Early Life Adversity Research, Dell Medical School, University of Texas at Austin (Nemeroff); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford (Rodriguez); Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco (State, Sanders).
Charles B NemeroffDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid (Parellada, Andreu-Bernabeu, Burdeus, San José Cáceres, Urbiola); CIBERSAM, Spain (Parellada, Burdeus, San José Cáceres); School of Medicine, Universidad Complutense, Madrid (Parellada); Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, and Butler Hospital, Providence, R.I. (Carpenter); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Mulva Clinic for the Neurosciences, Institute of Early Life Adversity Research, Dell Medical School, University of Texas at Austin (Nemeroff); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford (Rodriguez); Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco (State, Sanders).
Carolyn I RodriguezDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid (Parellada, Andreu-Bernabeu, Burdeus, San José Cáceres, Urbiola); CIBERSAM, Spain (Parellada, Burdeus, San José Cáceres); School of Medicine, Universidad Complutense, Madrid (Parellada); Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, and Butler Hospital, Providence, R.I. (Carpenter); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Mulva Clinic for the Neurosciences, Institute of Early Life Adversity Research, Dell Medical School, University of Texas at Austin (Nemeroff); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford (Rodriguez); Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco (State, Sanders).
Alik S WidgeDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid (Parellada, Andreu-Bernabeu, Burdeus, San José Cáceres, Urbiola); CIBERSAM, Spain (Parellada, Burdeus, San José Cáceres); School of Medicine, Universidad Complutense, Madrid (Parellada); Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, and Butler Hospital, Providence, R.I. (Carpenter); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Mulva Clinic for the Neurosciences, Institute of Early Life Adversity Research, Dell Medical School, University of Texas at Austin (Nemeroff); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford (Rodriguez); Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco (State, Sanders).
Matthew W StateDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid (Parellada, Andreu-Bernabeu, Burdeus, San José Cáceres, Urbiola); CIBERSAM, Spain (Parellada, Burdeus, San José Cáceres); School of Medicine, Universidad Complutense, Madrid (Parellada); Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, and Butler Hospital, Providence, R.I. (Carpenter); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Mulva Clinic for the Neurosciences, Institute of Early Life Adversity Research, Dell Medical School, University of Texas at Austin (Nemeroff); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford (Rodriguez); Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco (State, Sanders).
Stephan J SandersDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid (Parellada, Andreu-Bernabeu, Burdeus, San José Cáceres, Urbiola); CIBERSAM, Spain (Parellada, Burdeus, San José Cáceres); School of Medicine, Universidad Complutense, Madrid (Parellada); Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, and Butler Hospital, Providence, R.I. (Carpenter); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Mulva Clinic for the Neurosciences, Institute of Early Life Adversity Research, Dell Medical School, University of Texas at Austin (Nemeroff); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford (Rodriguez); Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco (State, Sanders).
Funding
4/4 - The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorderR01MH129751 · NIMH · UNIVERSITY OF OXFORD · PI Stephan Sanders · 2022 to 2026
$1.4M4/4 - The Autism Sequencing Consortium: Autism Gene Discovery in >50,000 ExomesU01MH111662 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SANDERS, STEPHAN, STATE, MATTHEW W. · 2017 to 2021
$1.3MNIMH NIH HHS R01 MH129751NIMH NIH HHS U01 MH111662
Abstract
objectiveThe aim of this study was to catalog and evaluate response biomarkers correlated with autism spectrum disorder (ASD) symptoms to improve clinical trials.
methodsA systematic review of MEDLINE, Embase, and Scopus was conducted in April 2020. Seven criteria were applied to focus on original research that includes quantifiable response biomarkers measured alongside ASD symptoms. Interventional studies or human studies that assessed the correlation between biomarkers and ASD-related behavioral measures were included.
resultsA total of 5,799 independent records yielded 280 articles for review that reported on 940 biomarkers, 755 of which were unique to a single publication. Molecular biomarkers were the most frequently assayed, including cytokines, growth factors, measures of oxidative stress, neurotransmitters, and hormones, followed by neurophysiology (e.g., EEG and eye tracking), neuroimaging (e.g., functional MRI), and other physiological measures. Studies were highly heterogeneous, including in phenotypes, demographic characteristics, tissues assayed, and methods for biomarker detection. With a median total sample size of 64, almost all of the reviewed studies were only powered to identify biomarkers with large effect sizes. Reporting of individual-level values and summary statistics was inconsistent, hampering mega- and meta-analysis. Biomarkers assayed in multiple studies yielded mostly inconsistent results, revealing a "replication crisis."
conclusionsThere is currently no response biomarker with sufficient evidence to inform ASD clinical trials. This review highlights methodological imperatives for ASD biomarker research necessary to make definitive progress: consistent experimental design, correction for multiple comparisons, formal replication, sharing of sample-level data, and preregistration of study designs. Systematic "big data" analyses of multiple potential biomarkers could accelerate discovery.
Indexed as
Autism Spectrum DisorderBiomarkersHumansMagnetic Resonance ImagingPhenotypeResearch DesignBiomarkersAutism Spectrum DisorderBiological MarkersClinical Drug StudiesClinical TrialsEndophenotypesPharmacodynamic BiomarkersResponse BiomarkersSymptom SeverityTranslational Research
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