Evidence map›Paper›PMID 36475284›Full record

ArticleOsteoarthritis and cartilage open2022

Infrared spectroscopy is suitable for objective assessment of articular cartilage health.

V Virtanen, V Tafintseva, R Shaikh, E Nippolainen, J Haas, I O Afara, J Töyräs, H Kröger, J Solheim, B Zimmermann and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 4 countries.

V VirtanenResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
V TafintsevaFaculty of Science and Technology, Norwegian University of Life Sciences, Ås, Norway.
R ShaikhDepartment of Applied Physics, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
E NippolainenDepartment of Applied Physics, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
J HaasInstitute of Analytical and Bioanalytical Chemistry, Ulm University, Ulm, Germany.
I O AfaraDepartment of Applied Physics, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
J TöyräsDepartment of Applied Physics, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
H KrögerDepartment of Orthopedics, Traumatology and Hand Surgery, Kuopio University Hospital, Kuopio, Finland.
J SolheimFaculty of Science and Technology, Norwegian University of Life Sciences, Ås, Norway.
B ZimmermannFaculty of Science and Technology, Norwegian University of Life Sciences, Ås, Norway.
A KohlerFaculty of Science and Technology, Norwegian University of Life Sciences, Ås, Norway.
B MizaikoffInstitute of Analytical and Bioanalytical Chemistry, Ulm University, Ulm, Germany.
M FinniläResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
L RieppoResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
S SaarakkalaResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Norwegian University of Life Sciences · NOUniversity of Eastern Finland · FIUniversity of Oulu · FIUniversität Ulm · DEKuopio University Hospital · FIOulu University Hospital · FIQueensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the feasibility of Fourier transform infrared attenuated total reflectance (FTIR-ATR) spectroscopy to detect cartilage degradation due to osteoarthritis and to validate the methodology with osteochondral human cartilage samples for future development towards clinical use. Design: Cylindrical ( Results: For all samples combined, classification accuracy was 73% with AUC of 0.79. Femoral samples had accuracy of 74% and AUC of 0.77, while tibial samples had accuracy of 66%, and AUC of 0.74. Patellar samples had accuracy of 84% and AUC of 0.91. Conclusions: The results indicate that FTIR-ATR spectroscopy can differentiate between healthy and osteoarthritic femoral, tibial and patellar human tissue. If combined with a fiber optic probe, FTIR-ATR spectroscopy could provide additional objective intraoperative information during arthroscopic surgeries, which could improve clinical outcomes.

Indexed as

ArthroscopyCartilageFourier transform infrared spectroscopyOsteoarthritis

Identifiers

PMID36475284
PMCPMC9718336
OpenAlexW4220852385

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.