Evidence map›Paper›PMID 36475028›Full record

ReviewInternational journal of health sciences

Cardiotoxicity in cancer patients treated with chemotherapy: A systematic review.

Maria Adriely Cunha Lima, Henrique Rodrigues de Almeida Brito, Gabriel Guimarães Mitidieri, Eduardo Paulo de Souza, Ana Caroline Gois Sobral, Hemmely Hevelyn Maria Araujo Melo, Guilherme Barreto Vasconcelos, Berila Beatriz Dias de Almeida, Thainá de Araújo Diniz Figueiredo, Marcello Augusto Anchieta Santos Filho and 3 more

Abstract readReview
In one paragraph

Review in International journal of health sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Design of New Daunorubicin Derivatives with High Cytotoxic Potential.International journal of molecular sciences · 2025
    Article
  7. Article
  8. Article
  9. CardioAI: A Multimodal AI-based System to Support Symptom Monitoring and Risk Prediction of Cancer Treatment-Induced Cardiotoxicity.Proceedings of the SIGCHI conference on human factors in computing systems. CHI Conference · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maria Adriely Cunha LimaUniversidade Tiradentes, Aracaju, Sergipe, Brazil.
Henrique Rodrigues de Almeida BritoUniversidade Tiradentes, Aracaju, Sergipe, Brazil.
Gabriel Guimarães MitidieriUniversidade Tiradentes, Aracaju, Sergipe, Brazil.
Eduardo Paulo de SouzaUniversidade Tiradentes, Aracaju, Sergipe, Brazil.
Ana Caroline Gois SobralUniversidade Tiradentes, Aracaju, Sergipe, Brazil.
Hemmely Hevelyn Maria Araujo MeloUniversidade Tiradentes, Aracaju, Sergipe, Brazil.
Guilherme Barreto VasconcelosUniversidade Tiradentes, Aracaju, Sergipe, Brazil.
Berila Beatriz Dias de AlmeidaUniversidade Tiradentes, Aracaju, Sergipe, Brazil.
Thainá de Araújo Diniz FigueiredoUniversidade Tiradentes, Aracaju, Sergipe, Brazil.
Marcello Augusto Anchieta Santos FilhoUniversidade Federal de Sergipe, Aracaju, Sergipe, Brazil.
Douglas Silva Rosendo SantosUniversidade Federal de Sergipe, Aracaju, Sergipe, Brazil.
Renan Fontes de CarvalhoUniversidade Federal de Sergipe, Aracaju, Sergipe, Brazil.
Halley Ferraro OliveiraUniversidade Tiradentes, Aracaju, Sergipe, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The objective of the study was to assess the incidence of chemotherapy cardiotoxicity. Methods: This is a systematic review carried out through the PubMed, VHL and Scientific Electronic Library Online databases, using the descriptors "Cardiotoxicity" and "Chemotherapy" associated with the Boolean operator "AND." Initially, 15,090 articles were found between 2015 and 2021. After applying the defined inclusion and exclusion criteria, 80 studies remained, of which 27 underwent complete reading, after which all were included in the study. Results: In total, 32,009 cancer patients were analyzed, of which 27,270 (85.2%) were female. Breast cancer was the most frequent neoplasm, with 11,145 (34.8%) cases. Regarding the type of chemotherapy, anthracycline was the most prevalent, analyzed in 18 (66.7%) studies, followed by trastuzumab, in 9 (33.3%) studies. Of the studies evaluated, five did not present any case of cardiotoxicity, a total of 2255 (8.3%) cases were recorded, in addition other outcomes mentioned in patients after chemotherapy were arrhythmia ( Conclusion: Post-chemotherapeutic cardiotoxicity was mentioned in most studies, being present in a relevant percentage of the sample. Furthermore, these patients may develop other cardiovascular events.

Indexed as

Cardiotoxicitychemotherapyoncology

Identifiers

PMID36475028
PMCPMC9682875

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.