ArticleOsteoarthritis and cartilage open2022
An open-label, single-arm trial of cryoneurolysis for improvements in pain, activities of daily living and quality of life in patients with symptomatic ankle osteoarthritis.
Article in Osteoarthritis and cartilage open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Article
- Cryoneurolysis for the management of pain secondary to obstetrical brachial plexus injury: a case report.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Article
- Ultrasound-guided peripheral nerve blocks for osteoarthritis pain management: a review of the genicular, suprascapular, PENG and deep peroneal nerve blocks.Frontiers in medicine · 2026Review
- Innovations in Chronic Pain Treatment: A Narrative Review on the Role of Cryoneurolysis.Medicina (Kaunas, Lithuania) · 2025Review
- A Narrative Review of Ultrasound-Guided and Landmark-based Percutaneous Cryoneurolysis for the Management of Acute and Chronic Pain.Current pain and headache reports · 2024Review
- Multisite treatment with percutaneous cryoneurolysis for the upper and lower limb in long-standing post-stroke spasticity.European journal of physical and rehabilitation medicine · 2024Article
- A Case Report of Cryoneurolysis for Dorsal Foot Pain and Toe Clawing in a Patient With Multiple Sclerosis.Archives of rehabilitation research and clinical translation · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Cryoneurolysis, cold-induced reversible conduction block of peripheral nerves, is an effective treatment for reducing knee osteoarthritis (OA) symptoms and opioid use following knee arthroplasty. There are however, limited data concerning its use for ankle OA. Our aim was to assess clinically significant long-term symptomatic relief of ankle OA with cryoneurolysis. Method: This single-center, open-label trial included participants aged >18 years with radiographic tibiotalar OA, unilateral ankle pain ≥5/10 on Numerical Rating Scale (NRS), and with no ankle surgery within 6-months of screening. Following ultrasound-guided cryoneurolysis of nerves in the participant's pain distribution (sural, saphenous, superficial and/or deep fibular nerves), outcomes were assessed at clinic visits (6, 12 and 24-weeks) and by telephone interview (3, 9, 18-weeks). The primary endpoint was change in Foot and Ankle Outcome Score (FAOS) (pain subscale) at 12-weeks. Change in quality of life (FAOS-QoL), activities of daily living (FAOS-ADL), NRS-pain, and physical performance measures were also assessed. Longitudinal mixed models were constructed to evaluate changes from baseline at 6, 12- and 24-weeks post-treatment. Results: Forty participants enrolled (50% female, mean ± SD age 63.0 ± 12.8 years). At 12-weeks post treatment, FAOS-pain (20.8, p < 0.0001), ADL (18.1, p = 0.0003), QoL (19.9, p = 0.0003) and NRS-pain (-2.6, p < 0.0001) were significantly improved from baseline. No difference in 40-m fast-paced walking test was detected at 12-weeks post-treatment (-1.2sec, p = 0.59). For all outcomes, similar findings were observed at 6- and 24-week visits. Conclusion: Cryoneurolysis resulted in statistically significant improvements in ankle pain, physical function and QoL for up to 24-weeks in participants with unilateral, symptomatic ankle OA.
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