Evidence map›Paper›PMID 36474883›Full record

ArticleOsteoarthritis and cartilage open2020

Cartilage collagen neoepitope C2C in urine as an integrative diagnostic marker for early knee osteoarthritis.

Liisa Kuhi, Ann E Tamm, Agu O Tamm, Kalle Kisand

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PubMed Full text at PMC Publisher
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Article in Osteoarthritis and cartilage open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Liisa KuhiDepartment of Internal Medicine, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Ann E TammSports Medicine and Rehabilitation Clinic, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Agu O TammDepartment of Internal Medicine, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Kalle KisandDepartment of Internal Medicine, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the suitability of urinary collagen type-II C-terminal cleavage neoepitope (uC2C) as a marker for early knee osteoarthritis (kOA). Design: We examined 302 Estonian subjects (mean age, 49 years): 186 subjects with and 20 control subjects without knee symptoms, and 96 patients treated by arthroscopy. For the latter, cartilage lesions were characterized using Société Francaise d'Arthroscopie (SFA) scores. Standardized radiographs of bilateral tibiofemoral (TF) and patellofemoral (PF) joints were assessed for osteoarthritis (OA) features. Osteophytes (Ophs) and joint space narrowing (JSN) were graded separately. uC2C was measured by the uC2C-HUSA assay. Logistic and linear regression models were used for data analysis. Results: Of the kOA cases, 50% were isolated (TF or PF) grade 1; 10% were grade 2. JSN with Ophs was more frequent in females than in males (52% vs. 34%, Conclusions: uC2C as an integrative marker of kOA is associated with cartilage degradation and Oph formation in the PF- and TF-joints. Increased uC2C concentration could be used as an early diagnostic marker for kOA in clinical studies.

Indexed as

AUC, area under the curveBMI, body mass indexCI, confidence intervalCol1, type I collagenCol2, type II collagengOA, radiographic global grade of kOAJoint space narrowingJSN, joint space narrowingKL grading, Kellgren and Lawrence radiographic gradingkOA, knee OAKOOS, Knee injury and Osteoarthritis Outcome Scorelm-models, linear regression modelsNeoepitope C2COA, osteoarthritisOph, osteophyteOR, odds ratioOsteoarthritisOsteophytesPatellofemoral jointPF, patellofemoralSD, standard deviationSFA score, Société Française d’Arthroscopie scoreTF, tibiofemoralTibiofemoral jointuC2C, Col2 cleavage neoepitopes in urine

Identifiers

PMID36474883
PMCPMC9718127

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.