Evidence map›Paper›PMID 36474875›Full record

ArticleOsteoarthritis and cartilage open2020

Metabolic and physiological effects of high intensity interval training in patients with knee osteoarthritis: A pilot and feasibility study.

Abbie E Smith-Ryan, Malia N M Blue, Kara C Anderson, Katie R Hirsch, Kelli D Allen, Janet L Huebner, Michael J Muehlbauer, Olga R Ilkayeva, Virginia Byers Kraus, William E Kraus and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03039452 (Feasibility and Initial Effects of High Intensity Interval Training on Knee Osteoarthritis), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03039452 nacompletednot on this map

Feasibility and Initial Effects of High Intensity Interval Training on Knee Osteoarthritis: an Exploratory Evaluation on Metabolomics

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2017 to 2017Enrolled15ConditionsKnee OsteoarthritisArmsHigh intensity interval training
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Abbie E Smith-RyanDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Malia N M BlueDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kara C AndersonDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Katie R HirschDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kelli D AllenThurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.
Janet L HuebnerDuke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Michael J MuehlbauerDuke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Olga R IlkayevaDuke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Virginia Byers KrausDuke Molecular Physiology Institute, Duke University, Durham, NC, USA.
William E KrausDuke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Yvonne M GolightlyThurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.
Kim M HuffmanDuke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Duke University · USUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To examine the feasibility of a 6-week high intensity interval training (HIIT) program in patients with symptomatic knee osteoarthritis (OA). A secondary aim was to evaluate the change in whole-body metabolism. Design: In a single-arm intervention, 16 adults (mean age 59.9 yrs; BMI: 29.0 ± 4.3 kg/m Results: Feasibility was moderate; of the 21 participants screened by phone, 16 were enrolled; 13 completed pre- and post-testing. The average adherence rate (sessions completed/available) was >96%. VO Conclusions: In this cohort of overweight adults with symptomatic knee OA, 6-weeks of HIIT cycling showed excellent rates of retention and adherence with no adverse events, improved cardiorespiratory fitness and OA symptoms, in concert with metabolic alterations indicative of improved skeletal muscle energetics. Trial registration number: clinicaltrials.gov: NCT03039452.

Indexed as

Exercise therapyInterval trainingMetabolomicsOsteoarthritisPain

Identifiers

PMID36474875
PMCPMC9718145
OpenAlexW3034219781

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.