ArticleEnvironmental epigenetics2022
Genetic and epigenetic interplay allows rapid transgenerational adaptation to metal pollution in zebrafish.
Article in Environmental epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Teleosts as Models for Epigenetic Inheritance.Molecular ecology · 2026Review
- Immune-Epigenetic Effects of Environmental Pollutants: Mechanisms, Biomarkers, and Transgenerational Impact.Current issues in molecular biology · 2025Review
- Complementary genetic and epigenetic changes facilitate rapid adaptation to multiple global change stressors.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Intergenerational effects of dietary iron on swimming and metabolic performance in zebrafish.Frontiers in physiology · 2025Article
- Sex-specific DNA methylation and transcription ofEpigenetics · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite still being a matter of debate, there is growing evidence that pollutant-induced epigenetic changes can be propagated across generations. Whereas such modifications could have long-lasting effects on organisms and even on population, environmentally relevant data from long-term exposure combined with follow-up through multiple generations remain scarce for non-mammalian species. We performed a transgenerational experiment comprising four successive generations of zebrafish. Only fish from the first generation were exposed to an environmentally realistic concentration of cadmium (Cd). Using a whole methylome analysis, we first identified the DNA regions that were differentially methylated in response to Cd exposure and common to fish of the first two generations. Among them, we then focused our investigations on the exon 3 (ex3) of the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.