ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2022
Lipid Accumulation Product Index Predicts New-Onset Type 2 Diabetes Among Non-Obese Koreans: A 12-Year Longitudinal Study.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lipid biomarkers for the prediction of type 2 diabetes risk, an umbrella review and updated meta-analyses of prospective observational studies.Frontiers in endocrinology · 2026Pooled it
- Comparison of the association and discriminatory ability of CVAI, LAP, CI, and AVI for type 2 diabetes in Chinese adults aged ≥ 50 years: a sex-specific analysis.Frontiers in endocrinology · 2026Article
- Effect of Qingre Lishi decoction on anthropometric and metabolic risk indices in obese patients with newly diagnosed T2DM: a real-world observational study.Frontiers in endocrinology · 2026Observational
- Association Between Lipid Accumulation Product and Stress Urinary Incontinence in Women in the United States: The Mediating Role of Oxidative Stress.International neurourology journal · 2025Article
- The association between lipid accumulation products and bone mineral density in U.S. Adults, a nationally representative cross-sectional study.Scientific reports · 2025Article
- Anthropometric and metabolic parameters associated with visceral fat in non-obese type 2 diabetes individuals.Diabetology & metabolic syndrome · 2025Article
- Correlation Analysis of Serum TYROBP Level and Metabolic Indexes of Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association between lipid accumulation product and non-alcoholic fatty liver disease with normal weight: a population-based study.Frontiers in medicine · 2025Article
- Non-linear relationship between lipid accumulation products and risk of diabetes in Japanese adults.Scientific reports · 2024Article
- Saturation Effect of Lipid Accumulation Product (LAP) Index on Spinal Bone Mineral Density: A Population-Based Study.Calcified tissue international · 2024Article
- Relationship between four visceral obesity indices and prediabetes and diabetes: a cross-sectional study in Dalian, China.BMC endocrine disorders · 2024Article
- Lipid accumulation product and type 2 diabetes risk: a population-based study.BMC endocrine disorders · 2024Article
- Lipid Accumulation Product as a Predictor of Prediabetes and Diabetes: Insights From NHANES Data (1999-2018).Journal of diabetes research · 2024Article
- Relationship between lipid accumulation product and new-onset diabetes in the Japanese population: a retrospective cohort study.Frontiers in endocrinology · 2023Article
- Positive correlation between lipid accumulation product index and arterial stiffness in Chinese patients with type 2 diabetes.Frontiers in endocrinology · 2023Article
- The predictive significance of lipid accumulation products for future diabetes in a non-diabetic population from a gender perspective: an analysis using time-dependent receiver operating characteristics.Frontiers in endocrinology · 2023Article
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5 authors.
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Abstract
Purpose: The lipid accumulation product (LAP) has been a potential indicator of central lipid accumulation status. This study aimed to assess the longitudinal association between LAP index and incident type 2 diabetes among non-obese Korean adults using a large, community-based Korean cohort observed over 12 years. Patients and Methods: This study included 4281 non-diabetic adults without generalized obesity and abdominal obesity and aged 40-69 years from the Korean Genome and Epidemiology Study. The participants were divided into four groups according to LAP index quartiles, calculated as (waist circumference [cm] - 65) x (triglycerides [mmol/L]) in men and (waist circumference [cm] - 58) x (triglycerides [mmol/L]) in women. We prospectively assessed hazard ratios (HRs) with 95% confidential intervals (CIs) for incident type 2 diabetes using multivariate Cox proportional hazard regression models. Results: Overall, 608 (14.2%) participants developed type 2 diabetes during the follow-up period. HRs for incident type 2 diabetes in the second, third, and fourth LAP quartile were 1.32 (95% CI: 0.97-1.79), 1.51 (95% CI: 1.11-2.06), and 2.14 (95% CI: 1.56-2.94), respectively, after adjusting for age, sex, body mass index, smoking status, alcohol intake, physical activity, mean arterial blood pressure, family history of diabetes, and impaired glucose tolerance. Conclusion: A high LAP index can be an additional indicator for new-onset T2DM among middle-aged and elderly non-obese Koreans.
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