ReviewOsteoarthritis and cartilage open
Osteoarthritis is a neurological disease - an hypothesis.
Review in Osteoarthritis and cartilage open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Neurobiology of osteoarthritis: a systematic review and activation likelihood estimation meta-analysis.Scientific reports · 2023Pooled it
- Pooled it
- Neuropathic-like pain in knee osteoarthritis: exploring differences in knee loading and inflammation. A cross-sectional study.European journal of physical and rehabilitation medicine · 2024Trial
- Cross-platform transcriptomic data integration identifies an overactive neuro-immune signature in human osteoarthritis synovium.Osteoarthritis and cartilage · 2026Article
- Post-traumatic osteoarthritis in aged rodents is associated with brain changes that correlate with joint remodeling.The journal of pain · 2026Article
- Identification of Potential Common Pathogenic Mechanisms Underlying Osteoarthritis and Major Depressive Disorder Using Bioinformatics Analysis.Immunity, inflammation and disease · 2025Article
- A validated set of neural gene reporter mice and chemical tracers tools for mapping knee innervating neurons.bioRxiv : the preprint server for biology · 2025Article
- Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2025Article
- Mapping the Brain's Role in Osteoarthritis: New Evidence for Prevention.Journal of multidisciplinary healthcare · 2025Article
- Review
- Clinical Assessment of Osteoarthritis Pain: Contemporary Scenario, Challenges, and Future Perspectives.Pain and therapy · 2024Review
- Development and validation of a nomogram for predicting motoric cognitive risk syndrome among community-dwelling older adults in China: a cross-sectional study.Frontiers in public health · 2024Article
- Neuromodulation as a Potential Disease-Modifying Therapy for Osteoarthritis.Current rheumatology reports · 2023Review
- Experimental models to study osteoarthritis pain and develop therapeutics.Osteoarthritis and cartilage open · 2022Review
- Long-Term Blockade of Nociceptive NaBiomolecules · 2022Article
- Joint Damage and Neuropathic Pain in Rats Treated With Lysophosphatidic Acid.Frontiers in immunology · 2022Article
- Cross-Disorder Genomics Data Analysis Elucidates a Shared Genetic Basis Between Major Depression and Osteoarthritis Pain.Frontiers in genetics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This commentary aims to summarise the importance of the joint nervous system in maintaining joint homeostasis and the role of nerves in contributing to degenerative diseases such as osteoarthritis (OA). Methods: Pertinent scientific literature was evaluated and summarised to form the hypothesis that OA is a neurological disease. Results: Joint nerves regulate a constant blood supply to maintain joint homeostasis and sustain tissue health; however, in OA this neurovascular control system is compromised and joint tissue integrity declines. Similarly, a decrease in joint proprioceptors and nociceptors with age and during arthritis interferes with position sense and pain transmission so that the body is unable to correct abnormal loading and this alteration in joint biomechanics can lead to joint destruction. Finally, brain morphology and activity are altered in OA patients but can be rectified by total joint replacement. Conclusions: Joints possess a complex nervous system that controls multiple physiological functions such as tissue blood flow, position sense, and pain. Damage or dysfunction of the joint nervous system can affect joint health and promote degenerative diseases such as OA. Drugs that are used to treat neurological diseases such as epilepsy and depression have been found to be effective at ameliorating the symptoms of OA. Thus, in addition to age, obesity, joint instability, and sex, neuronal impairment could be considered an additional risk factor for the development and pathogenesis of OA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.