Evidence map›Paper›PMID 36474655›Full record

ArticleBioactive materials2023

Neutrophil membrane-camouflaged nanoparticles alleviate inflammation and promote angiogenesis in ischemic myocardial injury.

Dongjian Han, Fuhang Wang, Zhentao Qiao, Bo Wang, Yi Zhang, Qingjiao Jiang, Miaomiao Liu, Yuansong Zhuang, Quanxu An, Yan Bai and 4 more

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Dongjian HanDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Fuhang WangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Zhentao QiaoDepartment of Vascular and Endovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Bo WangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Yi ZhangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Qingjiao JiangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Miaomiao LiuDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Yuansong ZhuangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Quanxu AnDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Yan BaiDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Jiahong ShangguanDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Jinying ZhangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Gaofeng LiangSchool of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, 471023, Henan, China.
Deliang ShenDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
First Affiliated Hospital of Zhengzhou University · CNHenan University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myocardial infarction (AMI) induces a sterile inflammatory response, leading to cardiomyocyte damage and adverse cardiac remodeling. Interleukin-5 (IL-5) plays an essential role in developing eosinophils (EOS), which are beneficial for the resolution of inflammation. Furthermore, the proangiogenic properties of IL-5 also contribute to tissue healing following injury. Therefore, targeted delivery of IL-5 is an innovative therapeutic approach for treating AMI. It has been shown that conventional IL-5 delivery can result in undesirable adverse effects and potential drug overdose. In this study, we successfully synthesized a biomimetic IL-5 nanoparticle by camouflaging the IL-5 nanoparticle in a neutrophilic membrane. The administration of neutrophil membrane-camouflaged nanoparticles (NM-NP

Indexed as

AngiogenesisBiomimetic nanoparticlesEosinophilsInterleukin-5Myocardial infarction

Identifiers

PMID36474655
PMCPMC9706603
OpenAlexW4310118211

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.