Evidence map›Paper›PMID 36474580›Full record

ArticleClinical interventions in aging2022

Detection Analysis of Perioperative Plasma and CSF Reveals Risk Biomarkers of Postoperative Delirium of Parkinson's Disease Patients Undergoing Deep Brain Stimulation of the Subthalamic Nuclei.

Yongde Zhou, Yu Ma, Cuiping Yu, Yao Chen, Jian Ding, Jianfeng Yu, Rongsong Zhou, Xiaoxiao Wang, Ting Fan, Chengmei Shi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical interventions in aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  4. Observational
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yongde ZhouDepartment of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing, People's Republic of China.
Yu MaDepartment of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing, People's Republic of China.
Cuiping YuDepartment of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing, People's Republic of China.
Yao ChenDepartment of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing, People's Republic of China.
Jian DingDepartment of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing, People's Republic of China.
Jianfeng YuDepartment of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing, People's Republic of China.
Rongsong ZhouDepartment of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing, People's Republic of China.
Xiaoxiao WangResearch Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, People's Republic of China.
Ting FanDepartment of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing, People's Republic of China.
Chengmei ShiDepartment of Anesthesiology, Peking University Third Hospital, Beijing, People's Republic of China.ORCID 0000-0003-4498-7241
Tsinghua University · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to explore possible biomarkers of postoperative delirium (POD) of Parkinson's disease (PD) patients received deep brain stimulation (DBS) of the subthalamic nuclei. Materials and methods: This nested case control study analyzed perioperative plasma and cerebral spinal fluid (CSF) of patients (n = 40) who developed POD undergone DBS surgery (n = 10) and those who did not (n = 30). Blood sample was collected before surgery and on the first day postoperative, CSF sample was collected at the beginning of the operation. POD was assessed by the Confusion Assessment Method (CAM) twice a day between 7:00 am and 7:00 pm after the surgery until discharge. Plasma and CSF sample from the two groups were analyzed to investigate possible biomarkers for POD in PD patients. Results: There was no difference between POD and Non-POD groups on the concentration of Interleukin 6 and Tumor Necrosis Factor-α in CSF, preoperative plasma and postoperative plasma. There was no difference between POD and Non-POD groups on the concentration of S100 calcium-binding protein β protein (S100β) and Neurofilament light chain (NFL) in preoperative plasma and postoperative plasma. The concentration of C-reactive protein (CRP), NFL and S100β were significant higher in POD group than non-POD group in CSF. The concentration of CRP was significantly higher in POD group than non-POD group in preoperative plasma and postoperative plasma. CSF concentration of S100β might be a potential biomarker for POD via the receiver operating characteristic curve analysis and the area under the curve value of 0.973. Conclusion: For PD patients received DBS surgery, CSF S100β might be a marker for aiding detection of high-risk patients with delirium. This requires further confirmation in clinical trials.

Indexed as

Deep Brain StimulationEmergence DeliriumParkinson DiseaseCase-Control StudiesHumansbiomarkercerebrospinal fluiddeep brain stimulationParkinson’s diseasepostoperative delirium

Identifiers

PMID36474580
PMCPMC9719687
OpenAlexW4310806154

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.