ArticleNature and science of sleep2022
Time Under 90% Oxygen Saturation and Systemic Hypertension in Patients with Obstructive Sleep Apnea Syndrome.
Article in Nature and science of sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 29 citations in OpenAlex.
- Resetting of the Human Circadian Melatonin Rhythm by Ambient Hypoxia.Journal of pineal research · 2025Trial
- Risk factors associated with hypertension in patients attending a pediatric sleep clinic: a prospective cohort study.European journal of pediatrics · 2026Article
- Review
- Towards generalizable contactless oximetry from multispectral video via deep domain-adaptive learning strategy.Biomedical optics express · 2026Article
- Mild Cognitive Impairment Associated with Obstructive Sleep Apnoea: A Pilot Study on Oxygen-Related Plasma Biomarkers and Network Analysis.Molecular neurobiology · 2026Article
- Differential cardiovascular and autonomic responses to structurally distinct intermittent hypoxia paradigms in rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Development and Validation of an Explainable Machine Learning Model for Identifying Hypertension Status in Patients With Obstructive Sleep Apnea.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Comparative Diagnostic Performance of Serum α-Klotho and FGF-23 in Predicting Obstructive Sleep Apnea Severity: A Novel Biomarker Approach.Journal of clinical medicine · 2026Article
- Severity classification of obstructive sleep apnea using AASM and SEPAR criteria: A cross-sectional reclassification analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Hypoxemia burden and atherogenic indices in OSAS: changes after CPAP therapy.Frontiers in medicine · 2026Article
- [The role of body roundness index and a body size index in the assessment of obstructive sleep apnea-hypopnea syndrome].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Article
- Sleep Apnea Specific Hypoxic Burden in Children With Down Syndrome and Typically Developing Children.Journal of sleep research · 2025Article
- Evaluation of retinal vascular structure via optic coherence tomography angiography in obstructive sleep apnea.International ophthalmology · 2025Article
- Association between skin temperature variability and sleep apnea severity: findings from a pilot study.Sleep & breathing = Schlaf & Atmung · 2025Article
- Patent foramen ovale (PFO) exacerbates intermittent hypoxia in moderate-to-severe obstructive sleep apnea (OSA) patients.Sleep & breathing = Schlaf & Atmung · 2025Article
- Upper airway and hyoid bone-related morphological parameters associated with the apnea-hypopnea index and lowest nocturnal oxygen saturation: a cephalometric analysis.BMC oral health · 2025Article
- The Association Between Craniofacial Morphological Parameters and the Severity of Obstructive Sleep Apnea: A Multivariate Analysis Using the Apnea-Hypopnea Index and Nocturnal Oxygen Desaturation.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Development and Validation of a Diagnostic Nomogram for Predicting Hypertension in Patients With Obstructive Sleep Apnea at High Altitude.International journal of hypertension · 2025Article
- [Construction of OSA-related hypertension prediction model based on nomogram].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The diagnosis and severity of obstructive sleep apnea (OSA) are commonly based on the apnea hypopnea index (AHI). However, patients with similar severity AHIs may show widely varying comorbidities and risks for cardiovascular disease, which may be associated with different severities of nocturnal hypoxia. The percentage of cumulative time with oxygen saturation below 90% in total sleep time (T90) is receiving increasing attention in OSA research because it describes the duration and degree of hypoxia during the whole sleep. This study aimed to explore the distribution of T90 in OSA patients with similar severity and to evaluate the relationship between T90 and hypertension. Patients and Methods: A total of 775 patients with OSA were enrolled in this study, all participants were divided into groups according to the T90 value: light hypoxia (T90≤5%), mild hypoxia (T90 accounted for 5-10%), moderate hypoxia (T90 accounted for 10-25%), and severe hypoxia (T90>25%). Multivariate logistic regression analysis was performed to assess the association between T90 and hypertension. Results: Of the patients with mild OSA, 94.33% had light hypoxia, and 88.64% of moderate OSA patients had light hypoxia. The proportions of light, mild, moderate, and severe hypoxia among patients with severe OSA were 28.60%, 17.69%, 21.40%, and 32.31%, respectively. After adjustment for potential confounders, the risk of hypertension in patients with severe OSA increased according to the severity categories of T90. The odds ratio for T90 accounting for 10-25% relative to T90≤5% was 2.544 (95%confidence interval, 1.254-5.164; P=0.010) and as high as 2.692 (95%confidence interval, 1.403-5.166; P=0.003) in patients with T90>25%. Conclusion: OSA patients with similar degree of AHI may have different T90 values, especially in severe OSA. A higher T90 was independently associated with the risk of hypertension after adjustment for traditional risk factors in patients with severe OSA. Our findings highlight the potential role for T90 in predicting hypertension in patients severe OSA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.