Evidence map›Paper›PMID 36474270›Full record

ArticleJournal of translational medicine2022

Polygenic risk of paclitaxel-induced peripheral neuropathy: a genome-wide association study.

Kosar Hooshmand, David Goldstein, Hannah C Timmins, Tiffany Li, Michelle Harrison, Michael L Friedlander, Craig R Lewis, Justin G Lees, Gila Moalem-Taylor, Boris Guennewig and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Polygenic risk scores in pharmacogenomics: methodological challenges, current applications, and perspectives for clinical implementation.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026
    Article
  4. Review
  5. Thematic evolution and research trends in chemotherapy-induced peripheral neuropathy: a bibliometric and visual analysis from 1992 to 2024.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Pharmacogenomics of chemotherapy induced peripheral neuropathy using an electronic health record-derived definition: a genome-wide association study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kosar HooshmandSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.
David GoldsteinPrince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.
Hannah C TimminsSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.ORCID 0000-0001-5504-1625
Tiffany LiSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.
Michelle HarrisonChris O'Brien Lifehouse, Camperdown, NSW, Australia.
Michael L FriedlanderPrince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.
Craig R LewisPrince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.
Justin G LeesSchool of Biomedical Sciences, University of New South Wales, UNSW Sydney, Sydney, NSW, Australia.
Gila Moalem-TaylorSchool of Biomedical Sciences, University of New South Wales, UNSW Sydney, Sydney, NSW, Australia.
Boris GuennewigSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.ORCID 0000-0002-6357-818X
Susanna B Park *School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.ORCID 0000-0003-0218-4707
John B Kwok *School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia. john.kwok@sydney.edu.au.ORCID 0000-0001-9574-6195
The University of Sydney · AUUNSW Sydney · AUChris O’Brien Lifehouse · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic risk factors for chemotherapy-induced peripheral neuropathy (CIPN), a major dose-limiting side-effect of paclitaxel, are not well understood.

methodsWe performed a genome-wide association study (GWAS) in 183 paclitaxel-treated patients to identify genetic loci associated with CIPN assessed via comprehensive neuropathy phenotyping tools (patient-reported, clinical and neurological grading scales). Bioinformatic analyses including pathway enrichment and polygenic risk score analysis were used to identify mechanistic pathways of interest.

resultsIn total, 77% of the cohort were classified with CIPN (n = 139), with moderate/severe neuropathy in 36%. GWAS was undertaken separately for the three measures of CIPN. GWAS of patient-reported CIPN identified 4 chromosomal regions that exceeded genome-wide significance (rs9846958, chromosome 3; rs117158921, chromosome 18; rs4560447, chromosome 4; rs200091415, chromosome 10). rs4560447 is located within a protein-coding gene, LIMCH1, associated with actin and neural development and expressed in the dorsal root ganglia (DRG). There were additional risk loci that exceeded the statistical threshold for suggestive genome-wide association (P < 1 × 10

conclusionsOur findings highlight the potential role of axon development and regeneration pathways in paclitaxel-induced CIPN.

Indexed as

Genome-Wide Association StudyPeripheral Nervous System DiseasesComputational BiologyGene OntologyHumansPaclitaxelPaclitaxelAxonChemotherapy-induced Peripheral NeuropathyGenome-wide association studyPaclitaxel

Identifiers

PMID36474270
PMCPMC9724416
OpenAlexW4311705744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.